ArticleInterface focus2019
Three-dimensional morphological analysis of placental terminal villi.
Article in Interface focus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Placental Blood-Flow Velocity Quantification From Diffusion MRI.Magnetic resonance in medicine · 2026Article
- The human placenta development and anatomy.Archives of gynecology and obstetrics · 2026Review
- Placental syncytial knots in the spectrum of maternal vascular malperfusion: mechanisms and clinical implications.Vascular biology (Bristol, England) · 2026Article
- Bioengineering approaches for patient-specific analysis of placenta structure and function.Placenta · 2025Article
- Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations.Cellular and molecular life sciences : CMLS · 2024Article
- Definition and Quantification of Three-Dimensional Imaging Targets to Phenotype Pre-Eclampsia Subtypes: An Exploratory Study.International journal of molecular sciences · 2023Article
- Three-dimensional morphological revealing of human placental villi with common obstetric complications via optical coherence tomography.Bioengineering & translational medicine · 2023Article
- Bioengineering Approaches for Placental Research.Annals of biomedical engineering · 2021Review
- Placentation in the Human and Higher Primates.Advances in anatomy, embryology, and cell biologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transport of nutrients and waste between the maternal and fetal circulations during pregnancy takes place at the final branches of the placental villous trees. Therefore, and unsurprisingly, pregnancy complications have been related to the maldevelopment of terminal villi. However, a deep analysis of placental villous morphology has been limited by tissue processing and imaging techniques. In this proof-of-principle study, placental lobules were fixed by perfusion and small clumps of villi were stained, sectioned optically and reconstructed. Morphological and network analyses were suggested and demonstrated on samples of normal placentas. The results show that most parameters are almost constant within a placenta but that there exists an inter-individual variation. Network analysis suggests that the feto-placental capillary network has several paths within an individual villus, serving as an efficient transport system. Three-dimensional reconstruction from confocal laser scanning microscopy images is a potent technique able to quantify placental architecture and capture the significant irregularities in vessel diameter and membrane thickness. This approach has the potential to become a powerful tool to further our understanding of the differences in placental structure which may underlie pregnancy complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.