ReviewIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2019
Effects of Early Enteral Glutamine Supplementation on Intestinal Permeability in Critically Ill Patients.
Review in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- The effects of high-protein vs conventional protein enteral nutrition on intestinal permeability, severity of disease, and mortality in critically ill intensive care unit Patients: Protocol for a randomized controlled trial.Contemporary clinical trials communications · 2026Article
- Traditional Chinese Medicine for Allergic Rhinitis: Mechanisms, Evidence, and Gut-Immune Axis Targets.Journal of asthma and allergy · 2026Review
- An integrated nutritional and performance monitoring framework for athletes with celiac disease: A structured narrative review.Current research in food science · 2026Review
- Oral low dose of glutamine improved the spontaneous closure in patients with external duodenal fistula: a retrospective comparative study with propensity score matching.Frontiers in nutrition · 2025Article
- Review
- Sodium Butyrate Attenuates AGEs-Induced Oxidative Stress and Inflammation by Inhibiting Autophagy and Affecting Cellular Metabolism in THP-1 Cells.Molecules (Basel, Switzerland) · 2022Article
- Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury.Neuropsychiatric disease and treatment · 2021Article
- Article
- Nutritional Management of Patients With Enterocutaneous Fistulas: Practice and Progression.Frontiers in nutrition · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsEnteral administration of glutamine has been proposed as an effective recovery of intestinal barrier function. This amino acid has a modulating effect on the reducing bacterial translocation, which can influence immune functions of the intestine. The objective was to evaluate the effects of early enteral glutamine supplementation on intestinal permeability in critically ill patients. MATERIALS AND
methodsA total of 80 critically ill patients older than 18 years were randomly assigned to one of two groups according to the stratified blocked randomization by age and admission category. Consecutive participants took enteral formula plus 0.3 g/kg/day glutamine powder or enteral formula plus maltodextrin during the ICU stay for a maximum of 10 days. Plasma glutamine, endotoxin, zonulin, and antiendotoxin immunoglobulin (Ig)G/IgM concentrations were measured on days 5 and 10 of intervention.
resultsOut of 80 participants, 36 patients in the glutamine group and 34 patients in the control group were included in the analysis of the outcomes. Enteral glutamine significantly reduced plasma zonulin concentration up to 40% during 10 days. This reduction was significantly greater compared with that of the placebo group (
conclusionEarly enteral glutamine supplementation led to a declined intestinal permeability in critically ill patients. HOW TO CITE THIS ARTICLE: Shariatpanahi ZV, Eslamian G, Ardehali SH, Baghestani AR. Effects of Early Enteral Glutamine Supplementation on Intestinal Permeability in Critically Ill Patients. Indian J Crit Care Med 2019;23(8):356-362.
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