ArticleNature2019
Maternal vitamin C regulates reprogramming of DNA methylation and germline development.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 117 citations in OpenAlex.
- Reprogramming the inactive X chromosome: dynamics and insights from the germline.Biochemical Society transactions · 2026Review
- H3K9me2 is a determinant for the mitosis-to-meiosis transition in female germ cells.Cell death & disease · 2026Article
- Ascorbic acid enhancesFrontiers in cell and developmental biology · 2026Article
- Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Vitamin C in Pregnancy: A Key Modulator of Fetal Growth and Epigenetic Stability.Current nutrition reports · 2025Review
- Article
- Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.bioRxiv : the preprint server for biology · 2025Article
- Highly Stable Sn─Pb Perovskite Solar Cells Enabled by Phenol-Functionalized Hole Transporting Material.Angewandte Chemie (International ed. in English) · 2025Article
- Oxidative Damage Under Microgravity Conditions: Response Mechanisms, Monitoring Methods and Countermeasures on Somatic and Germ Cells.International journal of molecular sciences · 2025Review
- Vitamin C-Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The physiological functions of ascorbate in the development of cancer.Disease models & mechanisms · 2025Review
- Exploring the Ascorbate Requirement of the 2-Oxoglutarate-Dependent Dioxygenases.Journal of medicinal chemistry · 2025Review
- Depression score and body mass index mediate the association between dietary vitamin C intake and female infertility: a study based on NHANES 2013-2018.Frontiers in nutrition · 2025Article
- Potentiation of Tumor Hallmarks by the Loss of GULO, a Vitamin C Biosynthesis Gene in Humans.Current molecular medicine · 2025Review
- Improving both performance and stability of n-type organic semiconductors by vitamin C.Nature materials · 2024Article
- Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Unraveling the 2,3-diketo-L-gulonic acid-dependent and -independent impacts of L-ascorbic acid on somatic cell reprogramming.Cell & bioscience · 2023Article
- Maternal vitamin B1 is a determinant for the fate of primordial follicle formation in offspring.Nature communications · 2023Article
- Article
- Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.Epigenetics & chromatin · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 9 institutions in 4 countries.
Stephanie P DiTroiaEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Michelle PerchardeEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Marie-Justine GuerquinUMR967 INSERM, CEA/DRF/iRCM/SCSR/LDG, Université Paris Diderot, Sorbonne Paris Cité, Université Paris-Sud, Université Paris-Saclay, Laboratory of Development of the Gonads, Fontenay aux Roses, France.
Estelle WallEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Evelyne CollignonLunenfeld-Tanenbaum Research Institute and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Kevin T EbataEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Kathryn MeshEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Swetha MahesulaChildren's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Michalis AgathocleousChildren's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Diana J LairdEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
Gabriel LiveraUMR967 INSERM, CEA/DRF/iRCM/SCSR/LDG, Université Paris Diderot, Sorbonne Paris Cité, Université Paris-Sud, Université Paris-Saclay, Laboratory of Development of the Gonads, Fontenay aux Roses, France.
Miguel Ramalho-SantosEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA. mrsantos@lunenfeld.ca.
Reproductive Science Center · USThe University of Texas Southwestern Medical Center · USUniversity of California, San Francisco · USBroad Center · USBroad Institute · USCEA Paris-Saclay · FRDélégation Paris 7 · FRImperial College London · GBLunenfeld-Tanenbaum Research Institute · CA
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MEnvironmental Modulation of Epigenetic Reprogramming in Pluripotent CellsR01OD012204 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAMALHO-SANTOS, MIGUEL · 2012 to 2016
$1.9MFmr1 Function and Repeat Expansion in the Developing GermlineR01GM122902 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAIRD, DIANA J · 2018 to 2021
$1.8MThe intersection of stress and environmental chemicals in germ cell reprogrammingR01ES028212 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAIRD, DIANA J · 2017 to 2021
$1.7MRegulation of developmental potency by the transposon LINE1R01GM123556 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2017 to 2020
$1.6MAssessing transgenerational effects of Phthalates on primordial germ cellsR21ES023297 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAIRD, DIANA J · 2013 to 2015
$944kMedical Research Council MC_UP_1605/4NIDDK NIH HHS P30 DK063720NIEHS NIH HHS R01 ES028212NIEHS NIH HHS R21 ES023297NIGMS NIH HHS R01 GM122902NIGMS NIH HHS R01 GM123556NIH HHS R01 OD012204
Abstract
Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential long-term consequences, including in mammals
Indexed as
AnimalsAscorbic AcidAscorbic Acid DeficiencyCell CountDNA-Binding ProteinsDNA MethylationEpigenomicsFemaleGerm CellsLoss of Function MutationMeiosisMiceModels, AnimalPregnancyProto-Oncogene ProteinsTranscriptomeAscorbic AcidDNA-Binding ProteinsProto-Oncogene ProteinsTET1 protein, mouse
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.