Evidence map›Paper›PMID 31485018›Full record

ArticleScientific reports2019

Inducing Mild Traumatic Brain Injury in C. elegans via Cavitation-Free Surface Acoustic Wave-Driven Ultrasonic Irradiation.

Morteza Miansari, Meghna D Mehta, Jan M Schilling, Yuta Kurashina, Hemal H Patel, James Friend

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Morteza MiansariMedically Advanced Devices Laboratory, Center for Medical Devices, Department of Mechanical and Aerospace Engineering, University of California San Diego, 9500 Gilman Drive MC0411, La Jolla, 92093, CA, United States of America.
Meghna D MehtaDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr MC0801, La Jolla, 92093, California, USA.
Jan M SchillingDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr MC0801, La Jolla, 92093, California, USA.
Yuta KurashinaMedically Advanced Devices Laboratory, Center for Medical Devices, Department of Mechanical and Aerospace Engineering, University of California San Diego, 9500 Gilman Drive MC0411, La Jolla, 92093, CA, United States of America.
Hemal H PatelDepartment of Anesthesiology, University of California San Diego, 9500 Gilman Dr MC0801, La Jolla, 92093, California, USA.
James FriendMedically Advanced Devices Laboratory, Center for Medical Devices, Department of Mechanical and Aerospace Engineering, University of California San Diego, 9500 Gilman Drive MC0411, La Jolla, 92093, CA, United States of America. jfriend@eng.ucsd.edu.
University of California, San Diego · USAdvanced Materials and Devices (United States) · USBabol Noshirvani University of Technology · IR

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Interdisciplinary Anesthesiology Research Training ProgramT32GM121318 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hemal H Patel, DAVID M ROTH · 2017 to 2026
$1.5M
NIGMS NIH HHS T32 GM121318NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mild traumatic brain injury is an all-too-common outcome from modern warfare and sport, and lacks a reproducible model for assessment of potential treatments and protection against it. Here we consider the use of surface acoustic wave (SAW) irradiation of C. elegans worms-without cavitation-as a potential, ethically reasonable animal-on-a-chip model for inducing traumatic brain injury in an animal, producing significant effects on memory and learning that could prove useful in a model that progress from youth to old age in but a few weeks. We show a significant effect by SAW on the ability of worms to learn post-exposure through associative learning chemotaxis. At higher SAW intensity, we find immediate, thorough, but temporary paralysis of the worms. We further explore the importance of homogeneous exposure of the worms to the SAW-driven ultrasound, an aspect poorly controlled in past efforts, if at all, and demonstrate the absence of cavitation through a change in fluids from a standard media for the worms to the exceedingly viscous polyvinyl alcohol. Likewise, we demonstrate that acoustic streaming, when present, is not directly responsible for paralysis nor learning disabilities induced in the worm, but is beneficial at low amplitudes to ensuring homogeneous ultrasound exposure.

Indexed as

AnimalsBrain ConcussionCaenorhabditis elegansDisease Models, AnimalUltrasonic Waves

Identifiers

PMID31485018
PMCPMC6726767
OpenAlexW2971786228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.