Evidence map›Paper›PMID 31484999›Full record

ArticleScientific reports2019

The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model.

Keigo Kanehara, Shinobu Ohnuma, Yoshitake Kanazawa, Keisuke Sato, Shoji Kokubo, Hideyuki Suzuki, Hideaki Karasawa, Takehiro Suzuki, Chitose Suzuki, Takeshi Naitoh and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Keigo KaneharaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Shinobu OhnumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. sohnuma@surg.med.tohoku.ac.jp.
Yoshitake KanazawaDepartment of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Keisuke SatoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Shoji KokuboDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Hideyuki SuzukiDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Hideaki KarasawaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Takehiro SuzukiDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Chitose SuzukiDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Takeshi NaitohDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan.ORCID http://orcid.org/0000-0002-2145-6416
Takaaki AbeDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, 980-8574, Japan. takaabe@med.tohoku.ac.jp.ORCID http://orcid.org/0000-0003-3170-4660
Tohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In inflammatory bowel disease, chronic inflammation results in the development of colon cancer known as colitis-associated cancer. This disease is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal fibrosis is a common clinical complication that is promoted by transforming growth factor β1 (TGF-β

Indexed as

AnimalsCarcinogenesisColonic NeoplasmsDextran SulfateDisease Models, AnimalFibronectinsHumansIndolesInterleukin-6MaleMiceMice, Inbred ICRTransforming Growth Factor beta1Tumor Necrosis Factor-alphaDextran SulfateFibronectinsIndolesInterleukin-6Transforming Growth Factor beta1Tumor Necrosis Factor-alpha

Identifiers

PMID31484999
PMCPMC6726640
OpenAlexW2971768658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.