ArticleScientific reports2019
Reduced synchronized brain activity in schizophrenia during viewing of comedy movies.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).Dialogues in clinical neuroscience · 2026Review
- Article
- Trait psychoticism is associated with greater intersubject neural dissimilarity during naturalistic social movie viewing.Scientific reports · 2026Article
- Humor processing and its relationship with clinical features in patients with first-episode schizophrenia.Schizophrenia research. Cognition · 2025Article
- Cerebral topographies of perceived and felt emotions.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis.BJPsych open · 2024Article
- High performers demonstrate greater neural synchrony than low performers across behavioral domains.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Consistent movement of viewers' facial keypoints while watching emotionally evocative videos.PloS one · 2024Article
- A normative model of brain responses to social scenarios reflects the maturity of children and adolescents' social-emotional abilities.Social cognitive and affective neuroscience · 2023Article
- Dynamic segregation and integration of brain functional networks associated with emotional arousal.iScience · 2023Article
- Inter-subject correlations of EEG reflect subjective arousal and acoustic features of music.Frontiers in human neuroscience · 2023Article
- Naturalistic Stimuli in Affective Neuroimaging: A Review.Frontiers in human neuroscience · 2021Review
- Social cognition in context: A naturalistic imaging approach.NeuroImage · 2020Review
- Intersubject Spatial Pattern Correlations During Movie Viewing Are Stimulus-Driven and Nonuniform Across the Cortex.Cerebral cortex communications · 2020Article
- Resilience-related neural similarity during naturalistic movie watching.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous evaluation of brain function in schizophrenia has focused on standard experimental tasks, with cerebral response to natural stimuli less clear. This study employed inter-subject correlation (ISC) analysis to investigate the neural basis of humor processing during free viewing of comedy movies in patients with schizophrenia. We recruited 29 patients diagnosed with schizophrenia and 29 healthy, age- and sex-matched controls. Each participant underwent fMRI scanning during two viewings of three comedy movie clips. The ISC map from each participant pair within each population group and each movie viewing was separately derived. The significance of ISC within a group and between two groups were assessed by bootstrapping. The ISC map from each patient pair were also correlated with the product of Positive and Negative Syndrome Scale (PANSS) rating between the same participant pair in schizophrenia patients. Schizophrenia patients showed significant ISC in bilateral lateraloccipital, bilateral superior frontal, left supramarginal, and right lateralorbiofrontal cortices. Compared with the controls, the schizophrenia group exhibited significantly lower ISC in the left superior temporal sulcus, bilateral supramarginal, and bilateral inferiorparietal cortices. Higher clinical severity (higher total PANSS rating) was associated with lower ISC in the middle frontal and middle temporal regions, and also higher ISC in the visual cortex, inferior temporal gyrus, and anterior cingulate. The findings indicated that patients with schizophrenia are characterized by lower ISC in a frontal parietal network while viewing comedy film clips, which implicated a deficit in the cognitive component of humor processing. The lower synchronization in parts of the frontal parietal network also correlated with symptom severity.
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