Evidence map›Paper›PMID 31484790›Full record

ReviewScience translational medicine2019

Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation.

Alvaro A Ordonez, Mark A Sellmyer, Gayatri Gowrishankar, Camilo A Ruiz-Bedoya, Elizabeth W Tucker, Christopher J Palestro, Dima A Hammoud, Sanjay K Jain

Abstract readReview
In one paragraph

Review in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Review
  2. Diagnostic Performance of [Journal of clinical medicine · 2026
    Article
  3. TheEuropean journal of nuclear medicine and molecular imaging · 2026
    Observational
  4. Review
  5. Article
  6. First-in-Human Biodistribution and Dosimetry of [Molecular imaging and biology · 2026
    Article
  7. Review
  8. Article
  9. Automated radiosynthesis of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025
    Article
  10. Review
  11. Biodistribution and dosimetry ofMedical physics · 2025
    Article
  12. Nature communications · 2025
    Observational
  13. DynamicAmerican journal of respiratory and critical care medicine · 2025
    Observational
  14. Article
  15. ACS infectious diseases · 2025
    Article
  16. Article
  17. Article
  18. Synthesis and Evaluation ofPharmaceutics · 2024
    Article
  19. Article
  20. Biological Evaluation of d-[Journal of medicinal chemistry · 2024
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alvaro A OrdonezCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8571-0655
Mark A SellmyerDepartment of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1407-1905
Gayatri GowrishankarMolecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9161-2701
Camilo A Ruiz-BedoyaCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-0653-4244
Elizabeth W TuckerCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-0971-3635
Christopher J PalestroDepartment of Radiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.ORCID 0000-0002-5998-832X
Dima A HammoudCenter for Infectious Disease Imaging, Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD 20814, USA.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. sjain5@jhmi.edu.ORCID 0000-0001-9620-7070

Funding

Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Molecular Imaging for Pulmonary Infections and InflammationR01HL131829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2016 to 2018
$2.2M
Next generation tools for imaging bacterial infection and its relationship to the immune systemDP5OD026386 · OD · UNIVERSITY OF PENNSYLVANIA · PI SELLMYER, MARK A · 2018 to 2022
$2.0M
Preclinical modeling to study Tuberculous MeningitisR56AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2019 to 2019
$839k
NHLBI NIH HHS R01 HL131829NIAID NIH HHS R56 AI145435NIBIB NIH HHS R01 EB020539NIBIB NIH HHS R01 EB025985NIH HHS DP5 OD026386
6 · The paper itself

Abstract

Clinical diagnostic tools requiring direct sample testing cannot be applied to infections deep within the body, and clinically available imaging tools lack specificity. New approaches are needed for early diagnosis and monitoring of bacterial infections and rapid detection of drug-resistant organisms. Molecular imaging allows for longitudinal, noninvasive assessments and can provide key information about infectious processes deep within the body.

Indexed as

Molecular ImagingTranslational Research, BiomedicalAnimalsBacterial InfectionsCost of IllnessHumansPatient SelectionPrecision Medicine

Identifiers

PMID31484790
PMCPMC6743081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.