Evidence map›Paper›PMID 31484788›Full record

ArticleScience translational medicine2019

Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa.

Angel S Byrd, Carmelo Carmona-Rivera, Liam J O'Neil, Philip M Carlucci, Cecilia Cisar, Avi Z Rosenberg, Michelle L Kerns, Julie A Caffrey, Stephen M Milner, Justin M Sacks and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 3 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 3 syntheses or guidelines pooled it, 166 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Nonclinical safety assessment of SBT777101, a CAR-engineered regulatory T cell therapy for autoimmune diseases.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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  12. Targeting Neutrophil Function as Therapy for Hidradenitis Suppurativa.International journal of molecular sciences · 2026
    Review
  13. Article
  14. Review
  15. Review
  16. Article
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  18. Article
  19. Review
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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Angel S ByrdDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mariana.kaplan@nih.gov carmelo.carmona-rivera@nih.gov angel_byrd@alumni.brown.edu.ORCID 0000-0001-5358-4247
Carmelo Carmona-RiveraSystemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. mariana.kaplan@nih.gov carmelo.carmona-rivera@nih.gov angel_byrd@alumni.brown.edu.ORCID 0000-0002-7706-1464
Liam J O'NeilSystemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Philip M CarlucciSystemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9729-4572
Cecilia CisarVA Palo Alto Health Care System, Palo Alto, CA, USA.
Avi Z RosenbergDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2356-950X
Michelle L KernsDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Julie A CaffreyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stephen M MilnerDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Justin M SacksDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Oluseyi AliuDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0228-5666
Kristen P BroderickDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jonathan S ReichnerDivision of Surgical Research, Department of Surgery, Rhode Island Hospital, Providence, RI, USA.ORCID 0000-0002-7349-6321
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8332-2210
Sewon KangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7841-9392
William H RobinsonVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID 0000-0003-4385-704X
Ginette A OkoyeDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1316-4023
Mariana J KaplanSystemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. mariana.kaplan@nih.gov carmelo.carmona-rivera@nih.gov angel_byrd@alumni.brown.edu.ORCID 0000-0003-2968-0815
Johns Hopkins University · USNational Institutes of Health · USVA Palo Alto Health Care System · USProvidence College · US

Funding

Systemic AutoimmunityZIAAR041199 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KAPLAN, MARIANA · 2014 to 2025
$32.5M
Intramural NIH HHS ZIA AR041199
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS), also known as acne inversa, is an incapacitating skin disorder of unknown etiology manifested as abscess-like nodules and boils resulting in fistulas and tissue scarring as it progresses. Given that neutrophils are the predominant leukocyte infiltrate in HS lesions, the role of neutrophil extracellular traps (NETs) in the induction of local and systemic immune dysregulation in this disease was examined. Immunofluorescence microscopy was performed in HS lesions and detected the prominent presence of NETs. NET complexes correlated with disease severity, as measured by Hurley staging. Neutrophils from the peripheral blood of patients with HS peripheral also displayed enhanced spontaneous NET formation when compared to healthy control neutrophils. Sera from patients recognized antigens present in NETs and harbored increased antibodies reactive to citrullinated peptides. B cell dysregulation, as evidenced by elevated plasma cells and IgG, was observed in the circulation and skin from patients with HS. Peptidylarginine deiminases (PADs) 1 to 4, enzymes involved in citrullination, were differentially expressed in HS skin, when compared to controls, in association with enhanced tissue citrullination. NETs in HS skin coexisted with plasmacytoid dendritic cells, in association with a type I interferon (IFN) gene signature. Enhanced NET formation and immune responses to neutrophil and NET-related antigens may promote immune dysregulation and contribute to inflammation. This, along with evidence of up-regulation of the type I IFN pathway in HS skin, suggests that the innate immune system may play important pathogenic roles in this disease.

Indexed as

AntigensAutoantibodiesB-LymphocytesCitrullinationExtracellular TrapsHeLa CellsHidradenitis SuppurativaHumansInterferon Type IPeptidesProtein-Arginine Deiminase Type 2Severity of Illness IndexAntigensAutoantibodiesInterferon Type IPADI2 protein, humanPeptidesProtein-Arginine Deiminase Type 2

Identifiers

PMID31484788
PMCPMC11369904
OpenAlexW2971609950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.