Evidence map›Paper›PMID 31484786›Full record

Trial reportThorax2020

Home initiation of chronic non-invasive ventilation in COPD patients with chronic hypercapnic respiratory failure: a randomised controlled trial.

Marieke L Duiverman, Judith M Vonk, Gerrie Bladder, Joost P van Melle, Jellie Nieuwenhuis, Anda Hazenberg, Huib A M Kerstjens, Job F M van Boven, Peter J Wijkstra

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02652559 (Treatment of Chronic Respiratory Failure in COPD Patients With Non-invasive Ventilation), which is not on this map. Cited by 89 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 11 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02652559 nacompletednot on this map

Treatment of Chronic Respiratory Failure in COPD Patients With Non-invasive Ventilation: Starting at Home and Selecting the Right Patient

TypeinterventionalSponsorUniversity Medical Center GroningenRan2016 to 2018Enrolled67ConditionsChronic Obstructive Pulmonary DiseaseArmsTranscutaneous measurements of PCO2, Telemonitoring, EMG, Home initiation of NIV, Inhospital initiation of NIV
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 11 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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  7. Admission avoidance hospital at home.The Cochrane database of systematic reviews · 2024
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Marieke L DuivermanDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands m.l.duiverman@umcg.nl.ORCID 0000-0002-8818-9447
Judith M VonkGroningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gerrie BladderDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joost P van MelleThoraxcenter, Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jellie NieuwenhuisDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anda HazenbergDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Huib A M KerstjensDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Job F M van BovenGroningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Peter J WijkstraDepartment of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic non-invasive ventilation (NIV) has become evidence-based care for stable hypercapnic COPD patients. While the number of patients increases, home initiation of NIV would greatly alleviate the healthcare burden. We hypothesise that home initiation of NIV with the use of telemedicine in stable hypercapnic COPD is non-inferior to in-hospital NIV initiation.

methodsSixty-seven stable hypercapnic COPD patients were randomised to initiation of NIV in the hospital or at home using telemedicine. Primary outcome was daytime arterial carbon dioxide pressure (PaCO

resultsHome NIV initiation was non-inferior to in-hospital initiation (adjusted mean difference in PaCO DISCUSSION: This is the first study showing that home initiation of chronic NIV in stable hypercapnic COPD patients, with the use of telemedicine, is non-inferior to in-hospital initiation, safe and reduces costs by over 50%. TRIAL REGISTRATION NUMBER: NCT02652559.

Indexed as

Patient ComplianceTelemedicineAgedCarbon DioxideChronic DiseaseFemaleForced Expiratory VolumeHospitalizationHospitalsHumansHypercapniaMaleMiddle AgedNoninvasive VentilationPartial PressurePulmonary Disease, Chronic ObstructiveCarbon DioxideCOPDnon-invasive ventilationtelemedicine

Identifiers

PMID31484786
PMCPMC7063397
OpenAlexW2971608349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.