Evidence map›Paper›PMID 31484766›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Structural basis for transcription activation by Crl through tethering of σ

Alexis Jaramillo Cartagena, Amy B Banta, Nikhil Sathyan, Wilma Ross, Richard L Gourse, Elizabeth A Campbell, Seth A Darst

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Transcription activation inEcoSal Plus · 2024
    Review
  5. RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  6. Article
  7. A negative feedback loop is critical for recovery of RpoS after stress inbioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. An SI3-σ arch stabilizes cyanobacteria transcription initiation complex.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexis Jaramillo CartagenaTri-Institutional Training Program in Chemical Biology, The Rockefeller University, New York, NY 10065.
Amy B BantaDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706.
Nikhil SathyanLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Wilma RossDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706.
Richard L GourseDepartment of Bacteriology, University of Wisconsin, Madison, WI 53706.
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065; darst@rockefeller.edu.ORCID 0000-0002-8241-3153
Rockefeller University · USUniversity of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

Structure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9M
MEDCHANISM, ACTIVATION, &CONTROL OF RRNA TRANSCRIPTIONR01GM037048 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GOURSE, RICHARD L. · 1986 to 2020
$5.9M
Structure/function analyses of essential mycobacterial transcription regulatorsR01GM114450 · NIGMS · ROCKEFELLER UNIVERSITY · PI CAMPBELL, ELIZABETH A · 2015 to 2023
$3.4M
NIGMS NIH HHS R01 GM037048NIGMS NIH HHS R01 GM114450NIGMS NIH HHS R35 GM118130
6 · The paper itself

Abstract

In bacteria, a primary σ-factor associates with the core RNA polymerase (RNAP) to control most transcription initiation, while alternative σ-factors are used to coordinate expression of additional regulons in response to environmental conditions. Many alternative σ-factors are negatively regulated by anti-σ-factors. In

Indexed as

Transcriptional ActivationBacterial ProteinsCryoelectron MicroscopyDNA-Directed RNA PolymerasesGene Expression Regulation, BacterialModels, MolecularMutationPromoter Regions, GeneticProtein BindingProtein ConformationSigma FactorTranscription FactorsBacterial ProteinsCrl protein, BacteriaDNA-Directed RNA PolymerasesSigma Factorsigma factor KatF protein, BacteriaTranscription Factorsbacterial stress responseCrlcryo-electron microscopyRNA polymeraseRpoS

Identifiers

PMID31484766
PMCPMC6754549
OpenAlexW2972273443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.