Evidence map›Paper›PMID 31484732›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.

Kelsey Roe, Geraldine L Shu, Kevin E Draves, Daniela Giordano, Marion Pepper, Edward A Clark

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
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  11. The Plasticity of Newly Formed B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kelsey RoeDepartment of Immunology, University of Washington, Seattle, WA 98109 kelsey.roe@seattlechildrens.org eaclark@uw.edu.ORCID 0000-0002-4319-3696
Geraldine L ShuDepartment of Immunology, University of Washington, Seattle, WA 98109.
Kevin E DravesDepartment of Immunology, University of Washington, Seattle, WA 98109.
Daniela GiordanoDepartment of Immunology, University of Washington, Seattle, WA 98109.ORCID 0000-0001-8362-7017
Marion PepperDepartment of Immunology, University of Washington, Seattle, WA 98109.
Edward A ClarkDepartment of Immunology, University of Washington, Seattle, WA 98109 kelsey.roe@seattlechildrens.org eaclark@uw.edu.ORCID 0000-0001-8061-5475
University of Washington · US

Funding

Programming protective immunity by targeting antigens to the CD180 receptorR01AI052203 · NIAID · UNIVERSITY OF WASHINGTON · PI FULLER, DEBORAH H. · 2003 to 2019
$6.3M
The Development and Function of Plasmodium-specific memory B cellsR01AI118803 · NIAID · UNIVERSITY OF WASHINGTON · PI PEPPER, MARION · 2017 to 2021
$3.0M
NIAID NIH HHS R01 AI052203NIAID NIH HHS R01 AI118803
6 · The paper itself

Abstract

Targeting Ags to the CD180 receptor activates both B cells and dendritic cells (DCs) to become potent APCs. After inoculating mice with Ag conjugated to an anti-CD180 Ab, B cell receptors were rapidly internalized. Remarkably, all B cell subsets, including even transitional 1 B cells, were programed to process, present Ag, and stimulate Ag-specific CD4

Indexed as

Antigen PresentationAnimalsAntigen-Presenting CellsAntigens, CDB-Cell Activation Factor ReceptorB-LymphocytesCD40 AntigensMiceMice, KnockoutRatsT-Lymphocytes, Helper-InducerAntigens, CDB-Cell Activation Factor ReceptorCD40 AntigensLy78 protein, mouseTnfrsf13c protein, mouse

Identifiers

PMID31484732
PMCPMC6761014
OpenAlexW2971865629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.