Evidence map›Paper›PMID 31484723›Full record

ArticleThe Journal of biological chemistry2019

Relative stabilities of wild-type and mutant glial fibrillary acidic protein in patients with Alexander disease.

Michael R Heaven, Landon Wilson, Stephen Barnes, Michael Brenner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Alexander disease: the road ahead.Neural regeneration research · 2023
    Review
  2. Roles of the cytoskeleton in human diseases.Molecular biology reports · 2023
    Review
  3. Article
  4. Alexander disease: models, mechanisms, and medicine.Current opinion in neurobiology · 2022
    Review
  5. GFAP at 50.ASN neuro
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Michael R HeavenDepartment of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, Alabama 35294.
Landon WilsonDepartment of Pharmacology and Toxicology, Targeted Metabolomics and Proteomics Laboratory, University of Alabama, Birmingham, Alabama 35294.
Stephen BarnesDepartment of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, Alabama 35294.
Michael BrennerDepartment of Neurobiology, University of Alabama, Birmingham, Alabama 35294 michaelb@uab.edu.
Target (United States) · USUniversity of Alabama at Birmingham · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
The impact of GFAP mutations upon filament networksP01NS042803 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2002 to 2012
$11.1M
UAB Skin Diseases Research CenterP30AR050948 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELMETS, CRAIG A · 2004 to 2013
$5.5M
5500 Q-Trap Mass SpectrometerS10RR027822 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, STEPHEN · 2010 to 2010
$469k
NCRR NIH HHS S10 RR027822NIAMS NIH HHS P30 AR050948NIDDK NIH HHS P30 DK079337NINDS NIH HHS P01 NS042803
6 · The paper itself

Abstract

Alexander disease (AxD) is an often fatal astrogliopathy caused by dominant gain-of-function missense mutations in the glial fibrillary acidic protein (

Indexed as

AdolescentAlexander DiseaseAmino Acid SequenceChildGlial Fibrillary Acidic ProteinHumansInfantMaleMutant ProteinsPeptidesProtein StabilityProteolysisReference StandardsGlial Fibrillary Acidic ProteinMutant ProteinsPeptidesAlexander diseaseastrocyteastrogliopathygenetic diseaseglial fibrillary acidic protein (GFAP)intermediate filamentMSmutantprotein stability

Identifiers

PMID31484723
PMCPMC6816090
OpenAlexW2972256582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.