Evidence map›Paper›PMID 31484688›Full record

ArticleGenetics2019

Modulating Mistranslation Potential of tRNA

Matthew D Berg, Yanrui Zhu, Julie Genereaux, Bianca Y Ruiz, Ricard A Rodriguez-Mias, Tyler Allan, Alexander Bahcheli, Judit Villén, Christopher J Brandl

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  4. Mistranslating tRNA variants impact the proteome and phosphoproteome ofbioRxiv : the preprint server for biology · 2025
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  9. Mistranslating tRNA variants have anticodon- and sex-specific impacts onbioRxiv : the preprint server for biology · 2024
    Article
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  12. Perseverance of protein homeostasis despite mistranslation of glycine codons with alanine.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Matthew D BergDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada mberg2@uwo.ca cbrandl@uwo.ca.ORCID 0000-0002-7924-9241
Yanrui ZhuDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.
Julie GenereauxDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.
Bianca Y RuizDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195.
Ricard A Rodriguez-MiasDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195.
Tyler AllanDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.
Alexander BahcheliDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.
Judit VillénDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195.ORCID 0000-0002-1005-1739
Christopher J BrandlDepartment of Biochemistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada mberg2@uwo.ca cbrandl@uwo.ca.ORCID 0000-0001-8015-9668
Western University · CAUniversity of Washington · US

Funding

Diversity Action Plan: UW GenOM ProjectR25HG007153 · NHGRI · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2020
$2.3M
Towards a comprehensive roadmap of cellular signaling.R35GM119536 · NIGMS · UNIVERSITY OF WASHINGTON · PI VILLEN, JUDIT · 2016 to 2020
$2.2M
NHGRI NIH HHS R25 HG007153NIGMS NIH HHS R35 GM119536
6 · The paper itself

Abstract

Transfer RNAs (tRNAs) read the genetic code, translating nucleic acid sequence into protein. For tRNA

Indexed as

Loss of Function MutationBase PairingProtein BiosynthesisRNA Processing, Post-TranscriptionalRNA StabilityRNA, Transfer, SerSaccharomyces cerevisiaeRNA, Transfer, Sermistranslationserine tRNAstatistical proteinssynthetic biologytRNA modifications

Identifiers

PMID31484688
PMCPMC6827378
OpenAlexW2971460580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.