Trial reportCritical care (London, England)2019
A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome.
Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01581229 (Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Use of Noninvasive Positive Pressure Ventilation for Intro-pulmonary Acute Lung Injury
Who cites it
41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Heterogeneity of surrogate outcome measures used in critical care studies: A systematic review.Clinical trials (London, England) · 2023Pooled it
- Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis.Critical care (London, England) · 2021Pooled it
- Non-invasive oxygenation strategies for respiratory failure with COVID-19: A concise narrative review of literature in pre and mid-COVID-19 era.Anaesthesia, critical care & pain medicine · 2021Pooled it
- Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis.British journal of anaesthesia · 2021Pooled it
- Pooled it
- Impact of CPAP and ventilator system resistance on respiratory effort in healthy volunteers.BMC pulmonary medicine · 2026Trial
- Effects of non-invasive respiratory supports on inspiratory effort in moderate-severe COVID-19 patients. A randomized physiological study.European journal of internal medicine · 2022Trial
- Awake Prone Positioning in Non-Intubated Non-COVID-19 ARDS: A Comprehensive Review.Advances in respiratory medicine · 2026Review
- Non-Invasive Respiratory Support in "De Novo" Acute Hypoxemic Respiratory Failure: Which Technique Is Best?Medicina (Kaunas, Lithuania) · 2026Review
- High-flow nasal oxygen is the reference treatment in acute hypoxemic respiratory failure: Pro.Journal of intensive medicine · 2025Review
- Noninvasive ventilation in acute hypoxemic respiratory failure: What is the future?Journal of intensive medicine · 2025Review
- Monitoring patients with acute respiratory failure during non-invasive respiratory support to minimize harm and identify treatment failure.Critical care (London, England) · 2025Review
- Impact of initial ventilation strategies on in-hospital mortality in sepsis patients: insights from the MIMIC-IV database.BMC pulmonary medicine · 2025Article
- Clinical review of non-invasive ventilation.The European respiratory journal · 2024Review
- Oxygen therapy and noninvasive respiratory supports in acute hypoxemic respiratory failure: a narrative review.Annals of intensive care · 2024Review
- Oxygen therapy in acute hypoxemic respiratory failure: guidelines from the SRLF-SFMU consensus conference.Annals of intensive care · 2024Article
- Optimal timing for intubation in patients on non-invasive ventilation: A retrospective cohort study.Health science reports · 2023Article
- Predictors of Failure of Noninvasive Ventilation in Critically Ill Children.Journal of pediatric intensive care · 2023Article
- ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.Intensive care medicine · 2023Article
- Efficacy and feasibility of awake proning in patients with COVID-19-related acute hypoxaemic respiratory failure: exploring both sides of the same coin.Irish journal of medical science · 2023Article
Corrections and comments
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Authors and funding
45 authors at 20 institutions in 1 country.
Hangyong HeDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Engineering Research Center for Diagnosis and Treatment of Pulmonary and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.ORCID http://orcid.org/0000-0001-9972-0929
Bing SunDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Engineering Research Center for Diagnosis and Treatment of Pulmonary and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
Lirong LiangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Engineering Research Center for Diagnosis and Treatment of Pulmonary and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
Yanming LiDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China.
He WangDepartment of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China.
Luqing WeiDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistics College of Chinese Armed Police Forces, Tianjin, China.
Guofeng LiDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistics College of Chinese Armed Police Forces, Tianjin, China.
Shuliang GuoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jun DuanDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuping LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Ying ZhouDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Yusheng ChenThe Pulmonary Department, Fujian Province Hospital, Fuzhou, Fujian Province, China.
Hongru LiThe Pulmonary Department, Fujian Province Hospital, Fuzhou, Fujian Province, China.
Jingping YangDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Inner Mongolia Medical College, Baotou, Inner Mongolia Autonomous Region, China.
Xiyuan XuDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Inner Mongolia Medical College, Baotou, Inner Mongolia Autonomous Region, China.
Liqiang SongThe Pulmonary Department, Xijing Hospital of the Fourth Military Medical University, Xi'an, Shanxi Province, China.
Jie ChenThe Pulmonary Department, Xijing Hospital of the Fourth Military Medical University, Xi'an, Shanxi Province, China.
Yong BaoThe Pulmonary Department, The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China.
Feng ChenThe Pulmonary Department, The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China.
Ping WangDepartment of Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China.
Lixi JiDepartment of Critical Care Medicine, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China.
Yongxiang ZhangDepartment of Respiratory Medicine, People's Hospital of Beijing Daxing District, Beijing, China.
Yanyan DingDepartment of Respiratory Medicine, People's Hospital of Beijing Daxing District, Beijing, China.
Liangan ChenDepartment of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
Ying WangDepartment of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
Lan YangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi Province, China.
Tian YangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi Province, China.
Heng WengThe Pulmonary Department, Lung Disease Hospital of Fujian Fuzhou, Fuzhou, Fujian Province, China.
Hongyan LiThe Pulmonary Department, Lung Disease Hospital of Fujian Fuzhou, Fuzhou, Fujian Province, China.
Daoxin WangThe Pulmonary Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jin TongThe Pulmonary Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yongchang SunThe Pulmonary Department, Beijing Tongren Hospital, Beijing, China.
Ran LiThe Pulmonary Department, Beijing Tongren Hospital, Beijing, China.
Faguang JinDepartment of Respiratory and Critical Care Medicine, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shanxi Province, China.
Chunmei LiDepartment of Respiratory and Critical Care Medicine, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shanxi Province, China.
Bei HeThe Pulmonary Department, Peking University Third Hospital, Beijing, China.
Lina SunThe Pulmonary Department, Peking University Third Hospital, Beijing, China.
Changzheng WangThe Pulmonary Department, Xinqiao Hospital Army Medical University, Chongqing, China.
Mingdong HuThe Pulmonary Department, Xinqiao Hospital Army Medical University, Chongqing, China.
Xiaohong YangDepartment of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
Qin LuoDepartment of Respiratory and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
Jin ZhangDepartment of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, China.
Hai TanDepartment of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, China.
Chen WangChinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. cyh-birm@263.net.
ENIVA Study Group
Army Medical University · CNCapital Medical University · CNWenzhou Medical University · CNBeijing Tongren Hospital · CNChinese PLA General Hospital · CNThird Affiliated Hospital of Inner Mongolia Medical College · CNThird People's Hospital of Chengdu · CNChengdu Fifth People's Hospital · CNDalian Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNFuzhou Pulmonary Hospital of Fujian · CNPeking University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNAir Force Medical University · CNBeijing Hospital · CNChina-Japan Friendship Hospital · CNNingxia Medical University · CNShaoxing People's Hospital · CNXijing Hospital · CN
Funding
National Natural Science Foundation of China 81490534National Science and Technology Pillar Program During the 12th Five-year Plan 2012BAI05B02
Abstract
rationaleOur pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with "early" stage of mild acute respiratory distress syndrome (ARDS, PaO
objectivesTo evaluate whether early NIV can reduce the need for invasive ventilation in patients with pneumonia-induced early mild ARDS.
methodsProspective, multicenter, randomized controlled trial (RCT) of NIV compared with conventional administration of oxygen through a Venturi mask. Primary outcome included the numbers of patients who met the intubation criteria.
resultsTwo hundred subjects were randomized to NIV (n = 102) or control (n = 98) groups from 21 centers. Baseline characteristics were similar in the two groups. In the NIV group, PaO
conclusionsTreatment with NIV did not reduce the need for intubation among patients with pneumonia-induced early mild ARDS, despite the improved PaO
trial registrationNCT01581229 . Registered 19 April 2012.
Indexed as
AdultAgedFemaleHumansMaleMiddle AgedNoninvasive VentilationPilot ProjectsProspective StudiesRespiratory Distress SyndromeSeverity of Illness IndexVentilator-Induced Lung InjuryAcute respiratory distress syndrome (ARDS)Noninvasive ventilation (NIV)Pneumonia
Identifiers
What OpenQuestion holds
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Registered trials
NCT01581229ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.