Evidence map›Paper›PMID 31484576›Full record

SynthesisCritical care (London, England)2019

The association between premorbid beta blocker exposure and mortality in sepsis-a systematic review.

Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean, Marek Nalos

Erratum issuedOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Metoprolol in Critically Ill Patients With COVID-19.Journal of the American College of Cardiology · 2021
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Observational
  10. Review
  11. Article
  12. Current Perspectives of Mitochondria in Sepsis-Induced Cardiomyopathy.International journal of molecular sciences · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Kaiquan TanNepean Clinical School, Sydney Medical School, University of Sydney, Penrith, Australia.
Martin HarazimMedical Intensive Care Unit, Teaching Hospital and Biomedical Centre, Charles University, Alej Svobody 80, 323 00, Pilsen, Czech Republic.
Benjamin TangNepean Clinical School, Sydney Medical School, University of Sydney, Penrith, Australia.
Anthony McleanNepean Clinical School, Sydney Medical School, University of Sydney, Penrith, Australia.
Marek NalosNepean Clinical School, Sydney Medical School, University of Sydney, Penrith, Australia. mareknalos@gmail.com.ORCID http://orcid.org/0000-0002-7977-9410
The University of Sydney · AUCharles University · CZ

Funding

Charles University Research Fund project number Q39Ministry of Youth and Education Services of the Czech Republic CZ.02.1.01/0.0/.0/16_019/0000787 "Fighting Infectious Diseases,"Nepean Institute of Critical Care Education and Research (NICCER) -
6 · The paper itself

Abstract

backgroundThe effect of premorbid β-blocker exposure on clinical outcomes in patients with sepsis is not well characterized. We aimed to examine the association between premorbid β-blocker exposure and mortality in sepsis.

methodsEMBase, MEDLINE, and Cochrane databases were searched for all studies of premorbid β-blocker and sepsis. The search was last updated on 22 June 2019. Two reviewers independently assessed, selected, and abstracted data from studies reporting chronic β-blocker use prior to sepsis and mortality. Main data extracted were premorbid β-blocker exposure, mortality, study design, and patient data. Two reviewers independently assessed the risk of bias and quality of evidence.

resultsIn total, nine studies comprising 56,414 patients with sepsis including 6576 patients with premorbid exposure to β-blockers were eligible. For the primary outcome of mortality, two retrospective studies reported adjusted odds ratios showing a reduction in mortality with premorbid β-blocker exposure. One study showed that premorbid β-blocker exposure decreases mortality in patients with septic shock. Another study showed that continued β-blockade during sepsis is associated with decreased mortality.

conclusionThis systematic review suggests that β-blocker exposure prior to sepsis is associated with reduced mortality. There was insufficient data to conduct a bona fide meta-analysis. Whether the apparent reduction in mortality may be attributed to the mitigation of catecholamine excess is unclear.

trial registrationPROSPERO, CRD42019130558 registered June 12, 2019.

Indexed as

Adrenergic beta-AntagonistsHumansHypertensionRetrospective StudiesSepsisAdrenergic beta-AntagonistsBeta blockersMortalitySepsisSystematic review

Identifiers

PMID31484576
PMCPMC6727531
OpenAlexW2971522116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.