ArticleBMC pediatrics2019
Prospective case control study of iron deficiency and the risk of febrile seizures in children in South Korea.
Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 40 citations in OpenAlex.
- Risk Factors for Initial Febrile Seizures in Pediatric Patients at Iranian Tertiary Hospitals (2019-2021): Retrospective Cross-Sectional Study.Iranian journal of child neurology · 2026Article
- An analysis on role of iron deficiency in febrile seizure among children in 6 months to 5 years: A case-control study.Journal of family medicine and primary care · 2024Article
- Review
- Quantitative susceptibility mapping shows lower brain iron content in children with childhood epilepsy with centrotemporal spikes.Japanese journal of radiology · 2023Article
- Multivariate linear mixture models for the prediction of febrile seizure risk and recurrence: a prospective case-control study.Scientific reports · 2023Article
- The Predictive Value of Hemocytometry Based on Peripheral Platelet-Related Parameters in Identifying the Causes of Febrile Seizures.Journal of inflammation research · 2021Article
- The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles.Frontiers in neurology · 2021Article
- Iron Deficiency Anemia in Children Residing in High and Low-Income Countries: Risk Factors, Prevention, Diagnosis and Therapy.Mediterranean journal of hematology and infectious diseases · 2020Review
- Effectiveness of prophylactic iron supplementation in the reduction of recurrence of febrile seizures in children: A prospective study with comparison with historical controls.Journal of neurosciences in rural practiceArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFebrile seizures are the most common type of seizure in the first 5 years of life, and many factors that increase seizure risk have been identified. This study was performed to examine the association between iron status and febrile seizures in children in South Korea.
methodsA prospective unmatched case control study was performed in 63 cases of febrile seizures and 65 controls with febrile illness but no seizures.
resultsSerum iron, plasma ferritin, and transferrin saturation were significantly lower in children with febrile seizures compared to the controls. Iron deficiency, defined as ferritin < 30 ng/mL, was more prevalent in the febrile seizure group (49.2%) than in the control group (16.9%). Serum iron < 22 ng/dL (odds ratio 3.42, 95% confidence interval [CI] 1.31-8.9, P = 0.012) and ferritin < 30 ng/mL (odds ratio 6.18, 95% CI 2.32-16.42, P < 0.001) were associated with increased risk of developing febrile seizures in multivariate logistic regression analysis.
conclusionThese observations suggest that iron deficiency prior to development of anemia may increase risk of febrile seizures.
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