Evidence map›Paper›PMID 31484462›Full record

SynthesisNutrients2019

Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis.

Javier Courel-Ibáñez, Tomas Vetrovsky, Klara Dadova, Jesús G Pallarés, Michal Steffl

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 11 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04734951 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of a Power/Resistance Exercise Program and Oral Supplementation With Beta-hydroxy-beta-methyl Butyrate (HMB) on the Muscle Quality Index in Older Adults. A Randomized Controlled Trial

TypeinterventionalSponsorInstituto Nacional de RehabilitacionRan2023 to 2024Enrolled76ConditionsAging WellArmsPower/resistance exercise program, HMB supplementation
NCT07660991 nacompletednot on this mapstarted 2025, after this paper: background citation

Pulmoner Rehabilitasyon Alan akciğer Nakil adaylarında hidroksimetilbütirat Takviyesinin değerlendirilmesi

TypeinterventionalSponsorOkan UniversityRan2025 to 2026Enrolled30ConditionsLung Transplantation, Pulmoner Rehabilitation, Lun Transplant CandidatesArmsHMB
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 11 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  7. Effects of exercise with or withoutFrontiers in nutrition · 2024
    Pooled it
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  12. Trial
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Javier Courel-IbáñezHuman Performance and Sports Science Laboratory, Faculty of Sport Sciences, University of Murcia, 30100 Murcia, Spain. javier.courel.ibanez@gmail.com.
Tomas VetrovskyFaculty of Physical Education and Sport, Charles University, Prague 16252, Czech Republic.
Klara DadovaFaculty of Physical Education and Sport, Charles University, Prague 16252, Czech Republic.
Jesús G PallarésHuman Performance and Sports Science Laboratory, Faculty of Sport Sciences, University of Murcia, 30100 Murcia, Spain.
Michal StefflFaculty of Physical Education and Sport, Charles University, Prague 16252, Czech Republic.
Charles University · CZUniversidad de Murcia · ES

Funding

Fundación Séneca 20872/PI/18Univerzita Karlova v Praze PRIMUS/19/HUM/012Univerzita Karlova v Praze project Q41
6 · The paper itself

Abstract

Both regular exercise training and beta-hydroxy-beta-methylbutyrate (HMB) supplementation are shown as effective treatments to delay or reverse frailty and reduce cognitive impairment in older people. However, there is very little evidence on the true benefits of combining both strategies. The aim of this meta-analysis was to quantify the effects of exercise in addition to HMB supplementation, on physical and cognitive health in older adults. Data from 10 randomized controlled trials (RCTs) investigating the effect of HMB supplementation and physical function in adults aged 50 years or older were analyzed, involving 384 participants. Results showed that HMB supplementation in addition to physical exercise has no or fairly low impact in improving body composition, muscle strength, or physical performance in adults aged 50 to 80 years, compared to exercise alone. There is a gap of knowledge on the beneficial effects of HMB combined with exercise to preserve cognitive functions in aging and age-related neurodegenerative diseases. Future RCTs are needed to refine treatment choices combining HMB and exercises for older people in particular populations, ages, and health status. Specifically, interventions in older adults aged 80 years or older, with cognitive impairment, frailty, or limited mobility are required.

Indexed as

AgingDietary SupplementsExerciseHumansValeratesbeta-hydroxyisovaleric acidValerateselderlyleucineneuromuscular functionnutritionresistance trainingsarcopenia

Identifiers

PMID31484462
PMCPMC6769498
OpenAlexW2972210583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.