Evidence map›Paper›PMID 31484452›Full record

ArticleAnimals : an open access journal from MDPI2019

Transcriptome Analysis of the Effects of Fasting Caecotrophy on Hepatic Lipid Metabolism in New Zealand Rabbits.

Yadong Wang, Huifen Xu, Guirong Sun, Mingming Xue, Shuaijie Sun, Tao Huang, Jianshe Zhou, Juan J Loor, Ming Li

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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  5. International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yadong WangCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. 18937802180@163.com.
Huifen XuCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. huifen221@126.com.
Guirong SunCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. grsun2000@126.com.
Mingming XueCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. 18538797878@163.com.
Shuaijie SunCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. 15738816518@163.com.
Tao HuangCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. xiaopangji77@163.com.
Jianshe ZhouCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. jianshezhou@yeah.net.
Juan J LoorMammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Champaign, IL 61801, USA. jloor@illinois.edu.
Ming LiCollege of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. 13803849306@163.com.
Henan Agricultural University · CNUniversity of Illinois Urbana-Champaign · US

Funding

National Key Research and Development Program of China 2018YFD0502203the Special Fund for Henan Agriculture Research System S2013-08-G01
6 · The paper itself

Abstract

In order to investigate the effects of fasting caecotrophy on hepatic lipid metabolism in rabbits, 12 weaned female New Zealand white rabbits were randomly divided into (n = 6/group) a control and fasting caecotrophy group. Rabbits in the experimental group were treated with an Elizabeth circle to prevent them from eating their own soft feces for a 60-day period. Growth and blood biochemical indices, transcriptome sequencing and histology analysis of the liver were performed. Compared with the control group, final weight, weight gain, liver weight, growth rate and feed conversion ratio, all decreased in the experimental group (p < 0.05). RNA sequencing (RNA-seq) analysis revealed a total of 301.2 million raw reads (approximately 45.06 Gb of high-quality clean data) that were mapped to the rabbit genome. After a five-step filtering process, 14,964 genes were identified, including 444 differentially expressed genes (p < 0.05, foldchange ≥ 1). A number of differently expressed genes linked to lipid metabolism were further analyzed including

Indexed as

fasting caecotrophylipid metabolismrabbitstranscriptome sequencing

Identifiers

PMID31484452
PMCPMC6769842
OpenAlexW2972122825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.