ArticleNeuroendocrinology2020
Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa.
Article in Neuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Underweight but not underfat: is fat-free mass a key factor in constitutionally thin women?European journal of clinical nutrition · 2021Pooled it
- Is constitutional thinness really different from anorexia nervosa? A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2021Pooled it
- Anxiety-metabolism networks in human anorexia nervosa: Responses to caloric and non-caloric meals in the Networks Integrating Anxiety and Metabolism in Anorexia Nervosa (NAMA) randomized trial.The British journal of nutrition · 2026Trial
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model.Gut microbes · 2026Article
- Metabolic regulation of synaptic plasticity in anorexia nervosa.Frontiers in synaptic neuroscience · 2026Review
- Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder.JAMA network open · 2025Article
- The gut-brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies.Pharmacology research & perspectives · 2024Review
- Lateral hypothalamic glutamatergic inputs to VTA glutamatergic neurons mediate prioritization of innate defensive behavior over feeding.Nature communications · 2024Article
- Challenges of considering both extremities of the weight status spectrum to better understand obesity: insights from the NUTRILEAN project in constitutionally thin individuals.International journal of obesity (2005) · 2023Article
- Article
- Review
- Hypothalamic volume is associated with body mass index.NeuroImage. Clinical · 2023Article
- How Can Animal Models Inform the Understanding of Cognitive Inflexibility in Patients with Anorexia Nervosa?Journal of clinical medicine · 2022Review
- Hypothalamic effective connectivity at rest is associated with body weight and energy homeostasis.Network neuroscience (Cambridge, Mass.) · 2022Article
- AMPA Receptor Function in Hypothalamic Synapses.Frontiers in synaptic neuroscience · 2022Review
- Lower hypothalamus subunit volumes link with impaired long-term body weight gain after preterm birth.Frontiers in endocrinology · 2022Article
- Article
- From Desire to Dread-A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa.Journal of clinical medicine · 2021Review
- The Role of the Gut Microbiome, Immunity, and Neuroinflammation in the Pathophysiology of Eating Disorders.Nutrients · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 4 countries.
Funding
Abstract
The hypothalamus contains integrative systems that support life, including physiological processes such as food intake, energy expenditure, and reproduction. Here, we show that anorexia nervosa (AN) patients, contrary to normal weight and constitutionally lean individuals, respond with a paradoxical reduction in hypothalamic levels of glutamate/glutamine (Glx) upon feeding. This reversal of the Glx response is associated with decreased wiring in the arcuate nucleus and increased connectivity in the lateral hypothalamic area, which are involved in the regulation on a variety of physiological and behavioral functions including the control of food intake and energy balance. The identification of distinct hypothalamic neurochemical dysfunctions and associated structural variations in AN paves the way for the development of new diagnostic and treatment strategies in conditions associated with abnormal body mass index and a maladaptive response to negative energy balance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.