Evidence map›Paper›PMID 31484080›Full record

ArticleCell reports2019

Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb.

Irene Gutierrez-Perez, M Jordan Rowley, Xiaowen Lyu, Viviana Valadez-Graham, Diana M Vallejo, Esther Ballesta-Illan, Jose P Lopez-Atalaya, Isaac Kremsky, Esther Caparros, Victor G Corces and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  5. bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Mechanistic drivers of chromatin organization into compartments.Current opinion in genetics & development · 2024
    Review
  9. Science advances · 2024
    Article
  10. Article
  11. eLife · 2024
    Article
  12. Article
  13. Polycomb Recruiters Inside and Outside of the Repressed Domains.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Irene Gutierrez-PerezInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan, Alicante, Spain.
M Jordan RowleyDepartment of Biology, Emory University, Atlanta, GA 30322, USA.
Xiaowen LyuDepartment of Biology, Emory University, Atlanta, GA 30322, USA.
Viviana Valadez-GrahamDepartment of Biology, Emory University, Atlanta, GA 30322, USA.
Diana M VallejoInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan, Alicante, Spain.
Esther Ballesta-IllanInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan, Alicante, Spain.
Jose P Lopez-AtalayaInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan, Alicante, Spain.
Isaac KremskyDepartment of Biology, Emory University, Atlanta, GA 30322, USA.
Esther CaparrosInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan, Alicante, Spain.
Victor G CorcesDepartment of Biology, Emory University, Atlanta, GA 30322, USA. Electronic address: vgcorces@gmail.com.
Maria DominguezInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan, Alicante, Spain. Electronic address: m.dominguez@umh.es.
Emory University · USConsejo Superior de Investigaciones Científicas · ESInstituto de Neurociencias · ES

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
MOLECULAR BASIS OF SUPPRESSION IN DROSOPHILAR01GM035463 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORCES, VICTOR G. · 1986 to 2020
$10.7M
Principals of Chromatin OrganizationR00GM127671 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ROWLEY, MICHAEL JORDAN · 2019 to 2021
$747k
Principles of Chromatin OrganizationK99GM127671 · NIGMS · EMORY UNIVERSITY · PI ROWLEY, MICHAEL JORDAN · 2018 to 2019
$120k
NIGMS NIH HHS K99 GM127671NIGMS NIH HHS R00 GM127671NIGMS NIH HHS R01 GM035463NIH HHS P40 OD018537
6 · The paper itself

Abstract

Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the psq gene, which has diverse roles in development and tumorigenesis, encodes distinct isoforms with unanticipated roles in genome 3D architecture. The BR-C, ttk, and bab domain (BTB)-containing Psq isoform (Psq

Indexed as

Amino Acid MotifsAnimalsCell LineChromatinDrosophila melanogasterDrosophila ProteinsEcdysoneEnhancer Elements, GeneticNuclear ProteinsPolycomb Repressive Complex 1Promoter Regions, GeneticProtein BindingProtein DomainsProtein IsoformsChromatinDrosophila ProteinsEcdysoneNuclear ProteinsPc protein, DrosophilaPolycomb Repressive Complex 1Protein Isoformspsq protein, Drosophilaarchitectural proteinchromatinCTCFepigeneticsGAFHiChIPhormonePipsqueakPOZ/BTBtranscription

Identifiers

PMID31484080
PMCPMC6754745
OpenAlexW2971714963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.