Evidence map›Paper›PMID 31484074›Full record

ArticleCell reports2019

A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy.

Ahmed O Hassan, Igor P Dmitriev, Elena A Kashentseva, Haiyan Zhao, Douglas E Brough, Daved H Fremont, David T Curiel, Michael S Diamond

Abstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
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  7. Article
  8. Review
  9. CD8Science advances · 2020
    Article
  10. Article
  11. COVID-19 vaccines and neglected pregnancy.Lancet (London, England) · 2020
    Article
  12. Review
  13. A Single Dose of NILV-Based Vaccine Provides Rapid and Durable Protection against Zika Virus.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed O HassanDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Igor P DmitrievDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Elena A KashentsevaDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Haiyan ZhaoDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Douglas E BroughPrecigen, 20358 Seneca Meadows Parkway, Germantown, MD 20876, USA.
Daved H FremontDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
David T CurielDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: diamond@wusm.wustl.edu.

Funding

Antibody-based Protection against FlavivirsesR01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, FREMONT, DAVED H. · 2007 to 2022
$11.4M
Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)R01HD091218 · NICHD · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, MYSOREKAR, INDIRA U · 2017 to 2022
$4.1M
Human neutralizing antibodies for Zika virusR01AI127828 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CROWE, JAMES E, DIAMOND, MICHAEL S · 2017 to 2021
$3.9M
GORILLA ADENOVIRUS ZIKA VACCINE FOR HUMANSR21AI131254 · NIAID · WASHINGTON UNIVERSITY · PI CURIEL, DAVID TERRY · 2017 to 2018
$419k
NIAID NIH HHS R01 AI073755NIAID NIH HHS R01 AI127828NIAID NIH HHS R21 AI131254NICHD NIH HHS R01 HD091218
6 · The paper itself

Abstract

The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) proteins (GAd-Zvp) or prM and the ectodomain of E protein (GAd-Eecto). Both vaccines induce humoral and cell-mediated immune responses and prevent lethality after ZIKV challenge in mice. Protection is antibody dependent, CD8

Indexed as

ImmunityAdenoviridaeAnimalsAntibody FormationB-LymphocytesFemaleFetusGorilla gorillaHumansImmunologic MemoryMice, Inbred C57BLPregnancyT-LymphocytesViral VaccinesZika VirusViral Vaccinesadaptive immunityflaviviruspathogenesispregnancyvaccineZika virus

Identifiers

PMID31484074
PMCPMC6750284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.