ArticleCell reports2019
White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- A Proposed Novel Neurovascular Mechanism for Brain Network Dysfunction After Traumatic Injury.Annals of biomedical engineering · 2026Article
- Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity.Nature communications · 2026Article
- Structural and Functional Connectivity Predict the Effects of Direct Brain Stimulation on Memory.bioRxiv : the preprint server for biology · 2026Article
- Controlling the human connectome with spatially diffuse input signals.Communications biology · 2026Article
- Habit learning is associated with efficiently controlled network dynamics in naive macaque monkeys.Npj complexity · 2026Article
- Optimal stochastic tracking control for brain network dynamics.Communications biology · 2025Article
- Inferring intrinsic neural timescales using optimal control theory.Nature communications · 2025Article
- Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy.Nature communications · 2025Article
- Biophysically constrained dynamical modelling of the brain using multimodal magnetic resonance imaging.Brain research bulletin · 2025Article
- Article
- Long-term potentiation and long-term depression are both impaired afterBiomedical physics & engineering express · 2025Article
- Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.bioRxiv : the preprint server for biology · 2025Article
- Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience.Communications biology · 2025Article
- The control costs of human brain dynamics.Network neuroscience (Cambridge, Mass.) · 2025Article
- Brain Network Controllability and Its Regional Gene Expression Profile Associated With Suicidal Tendencies in Major Depressive Disorder Patients.Depression and anxiety · 2025Article
- A network control theory pipeline for studying the dynamics of the structural connectome.Nature protocols · 2024Article
- Predicting the effect of micro-stimulation on macaque prefrontal activity based on spontaneous circuit dynamics.Physical review research · 2024Article
- Why does invasive brain stimulation sometimes improve memory and sometimes impair it?PLoS biology · 2024Article
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Optimizing direct electrical stimulation for the treatment of neurological disease remains difficult due to an incomplete understanding of its physical propagation through brain tissue. Here, we use network control theory to predict how stimulation spreads through white matter to influence spatially distributed dynamics. We test the theory's predictions using a unique dataset comprising diffusion weighted imaging and electrocorticography in epilepsy patients undergoing grid stimulation. We find statistically significant shared variance between the predicted activity state transitions and the observed activity state transitions. We then use an optimal control framework to posit testable hypotheses regarding which brain states and structural properties will efficiently improve memory encoding when stimulated. Our work quantifies the role that white matter architecture plays in guiding the dynamics of direct electrical stimulation and offers empirical support for the utility of network control theory in explaining the brain's response to stimulation.
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Registered trials
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