Evidence map›Paper›PMID 31484052›Full record

ArticleCell metabolism2019

Host-Pathogen Relationship Advice: Fat Protects against a Broken Heart.

Justin L McCarville, Janelle S Ayres

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Justin L McCarvilleMolecular and Systems Physiology Laboratory, Gene Expression Laboratory, The Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Janelle S AyresMolecular and Systems Physiology Laboratory, Gene Expression Laboratory, The Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: jayres@salk.edu.

Funding

Tolerance defenses in host-microbiota interactionsR01AI114929 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AYRES, JANELLE S · 2015 to 2025
$4.9M
NIAID NIH HHS R01 AI114929
6 · The paper itself

Abstract

During infection, disease tolerance promotes host health without killing the pathogen. In a recent issue of Cell, Luan et al. (2019) identify GDF15 as a central regulator of disease tolerance of bacterial and viral challenges, while preventing cardiac damage, by mediating downstream cross-organ communication via the sympathetic and metabolic systems.

Indexed as

Host-Pathogen InteractionsImmune ToleranceGrowth Differentiation Factor 15HumansInflammationGDF15 protein, humanGrowth Differentiation Factor 15

Identifiers

PMID31484052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.