Evidence map›Paper›PMID 31483993›Full record

ArticleMolecular pharmaceutics2019

Dual Radionuclide Theranostic Pretargeting.

Outi Keinänen, James M Brennan, Rosemery Membreno, Kimberly Fung, Kishore Gangangari, Eric J Dayts, Carter J Williams, Brian M Zeglis

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
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  11. Review
  12. Article
  13. Review
  14. Radiolabeling of Theranostic Nanosystems.Advances in experimental medicine and biology · 2021
    Article
  15. HarnessingProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Outi KeinänenDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
James M BrennanDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
Rosemery MembrenoDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
Kimberly FungDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
Kishore GangangariDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
Eric J DaytsDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
Carter J WilliamsDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.
Brian M ZeglisDepartment of Chemistry , Hunter College, City University of New York , New York , New York 10021 , United States.ORCID 0000-0002-9091-744X
City University of New York · USThe Graduate Center, CUNY · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Memorial Sloan Kettering Small Animal Imaging ResearchR24CA083084 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI KOUTCHER, JASON ARTHUR · 1999 to 2006
$4.4M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS R24 CA083084NCI NIH HHS U01 CA221046
6 · The paper itself

Abstract

Recent years have played witness to the advent of nuclear theranostics: the synergistic use of "matched pair" radiopharmaceuticals for diagnostic imaging and targeted radiotherapy. In this investigation, we report the extension of this concept to in vivo pretargeting based on the rapid and bioorthogonal inverse electron demand Diels-Alder reaction between tetrazine (Tz) and

Indexed as

Theranostic NanomedicineAnimalsColorectal NeoplasmsCopper RadioisotopesCyclooctanesFemaleHeterocyclic Compounds, 1-RingHumansImmunoconjugatesLutetiumMembrane GlycoproteinsMiceMice, NudePositron-Emission TomographyRadioimmunotherapyRadioisotopesCopper-64Copper RadioisotopesCyclooctanesGPA33 protein, humanHeterocyclic Compounds, 1-RingImmunoconjugatesLutetiumLutetium-177Membrane GlycoproteinsRadioisotopesRadiopharmaceuticalstetrazine dye 10A33 antigenbioorthogonal chemistryclick chemistrycolorectal cancerhuA33inverse electron demand Diels−Alder reactionmultistep targetingPETpositron emission tomographypretargeted radioimmunotherapypretargetingtetrazinetheranosticstrans-cyclooctene

Identifiers

PMID31483993
PMCPMC7169955
OpenAlexW2972303578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.