ArticleJournal of biophotonics2020
Pathological crystal imaging with single-shot computational polarized light microscopy.
Article in Journal of biophotonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- A Novel Polarized Light Microscope for the Examination of Birefringent Crystals in Synovial Fluid.Gout, urate, and crystal deposition disease · 2024Article
- Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array.Nature communications · 2024Article
- Ptychographic lens-less birefringence microscopy using a mask-modulated polarization image sensor.Scientific reports · 2023Article
- Detection of crystals in joint fluid aspirates with polychromatic polarisation microscopy.Annals of the rheumatic diseases · 2023Article
- Polarization multiplexed diffractive computing: all-optical implementation of a group of linear transformations through a polarization-encoded diffractive network.Light, science & applications · 2022Article
- Quantitative Jones matrix imaging using vectorial Fourier ptychography.Biomedical optics express · 2022Article
- Label-free microscopy of mitotic chromosomes using the polarization orthogonality breaking technique.Biomedical optics express · 2021Article
- Calcium pyrophosphate crystal size and characteristics.Osteoarthritis and cartilage open · 2021Article
- Deep Learning-Based Holographic Polarization Microscopy.ACS photonics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pathological crystal identification is routinely practiced in rheumatology for diagnosing arthritis disease such as gout, and relies on polarized light microscopy as the gold standard method used by medical professionals. Here, we present a single-shot computational polarized light microscopy method that reconstructs the transmittance, retardance and slow-axis orientation of a birefringent sample using a single image captured with a pixelated-polarizer camera. This method is fast, simple-to-operate and compatible with all the existing standard microscopes without extensive or costly modifications. We demonstrated the success of our method by imaging three different types of crystals found in synovial fluid and reconstructed the birefringence information of these samples using a single image, without being affected by the orientation of individual crystals within the sample field-of-view. We believe this technique will provide improved sensitivity, specificity and speed, all at low cost, for clinical diagnosis of crystals found in synovial fluid and other bodily fluids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.