ArticlePloS one2019
Increased functional connectivity of thalamic subdivisions in patients with Parkinson's disease.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07599592 (Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor
Who cites it
20 citing papers in PubMed.
- Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Alterations in relative perfusion and synaptic patterns in Parkinson's disease using dynamic SV2A PET.medRxiv : the preprint server for health sciences · 2026Article
- Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Functional brain connectivity in patients withNeuroimage. Reports · 2026Article
- Novel psychophysical line bisection task using brief stimulus presentation reveals no horizontal bias in left-onset parkinson's disease.Scientific reports · 2026Article
- Volumetric signatures of basal ganglia-thalamo-cortical and cerebello-thalamo-cortical networks in Parkinson's disease and its motor subtypes.Frontiers in aging neuroscience · 2026Article
- Early classification of functional connectomes in Parkinson's disease: a comparison of machine learning classifiers using multi-scale topological features.BMC medical informatics and decision making · 2025Article
- The FinnBrain multimodal neonatal template and atlas collection.Communications biology · 2025Article
- Functional connectivity of thalamic nuclei during sensorimotor task-based fMRI at 9.4 Tesla.Frontiers in neuroscience · 2025Article
- A worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Disuse-driven plasticity in the human thalamus and putamen.bioRxiv : the preprint server for biology · 2024Article
- Structural and functional differences of the thalamus between drug-naïve Parkinson's disease motor subtypes.Frontiers in neurology · 2023Article
- Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional connectivity of the cortico-subcortical sensorimotor loop is modulated by the severity of nigrostriatal dopaminergic denervation in Parkinson's Disease.NPJ Parkinson's disease · 2022Article
- Subcortical and hippocampal brain segmentation in 5-year-old children: Validation of FSL-FIRST and FreeSurfer against manual segmentation.The European journal of neuroscience · 2022Article
- Body-mind relaxation meditation modulates the thalamocortical functional connectivity in major depressive disorder: a preliminary resting-state fMRI study.Translational psychiatry · 2021Article
- The exploration of Parkinson's disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data.Brain imaging and behavior · 2021Article
- Dorsal and ventral striatal functional connectivity shifts play a potential role in internet gaming disorder.Communications biology · 2021Article
- More Than Just Static: Dynamic Functional Connectivity Changes of the Thalamic Nuclei to Cortex in Parkinson's Disease With Freezing of Gait.Frontiers in neurology · 2021Article
- Biodegradable lipid nanoparticles for genome editing in the brain via intrathecal administration.Materials today (Kidlington, England)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) affects 2-3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with putative connections to prefrontal cortices. We then investigated potential differences in the size and shape of the thalamus in PD, and how morphology and functional connectivity relate to clinical variables. Our data demonstrate that PD is associated with increases in functional connectivity between motor subdivisions of the thalamus and the supplementary motor area, and between prefrontal thalamic subdivisions and nuclei of the basal ganglia, anterior and dorsolateral prefrontal cortices, as well as the anterior and paracingulate gyri. These results suggest that PD is associated with increased functional connectivity of subdivisions of the thalamus which may be indicative alterations to basal ganglia-thalamocortical circuitry.
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