ArticlePloS one2019
Sex and racial differences in cardiovascular disease risk in patients with atrial fibrillation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use of Antihypertensives, Blood Pressure, and Estimated Risk of Dementia in Late Life: An Individual Participant Data Meta-Analysis.JAMA network open · 2023Pooled it
- Differences in the use of pharmacologic and nonpharmacologic treatments among patients with chronic low back pain between 2017 and 2021: A cross-sectional study of commercial claims.The journal of pain · 2026Article
- Old and new equations for maximal and anaerobic threshold heart rate prediction in coronary heart disease in Chinese population.BMC cardiovascular disorders · 2024Article
- The bidirectional association between atrial fibrillation and myocardial infarction.Nature reviews. Cardiology · 2023Review
- Cluster analysis reveals distinct patterns of childhood adversity, behavioral disengagement, and depression that predict blunted heart rate reactivity to acute psychological stress.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Article
- The prevalence of atrial fibrillation in Greenland: a register-based cross-sectional study based on disease classifications and prescriptions of oral anticoagulants.International journal of circumpolar health · 2022Article
- Re-Visiting Maximal Heart Rate Prediction Using Cross-Validation in Population Aged 7-55 Years.International journal of environmental research and public health · 2022Article
- Relation of Household Income to Access and Adherence to Combination Sacubitril/Valsartan in Heart Failure: A Retrospective Analysis of Commercially Insured Patients.Circulation. Cardiovascular quality and outcomes · 2022Article
- Sex differences in treatment strategy and adverse outcomes among patients 75 and older with atrial fibrillation in the MarketScan database.BMC cardiovascular disorders · 2021Article
- Stroke risk factors and outcomes among hospitalized women with atrial fibrillation.Journal of thrombosis and thrombolysis · 2021Observational
- Social determinants of atrial fibrillation.Nature reviews. Cardiology · 2021Review
- Disparities in Anticoagulant Therapy Initiation for Incident Atrial Fibrillation by Race/Ethnicity Among Patients in the Veterans Health Administration System.JAMA network open · 2021Article
- Atrial fibrillation in low- and middle-income countries: a narrative review.European heart journal supplements : journal of the European Society of Cardiology · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundOutcomes among atrial fibrillation (AF) patients may differ according to race/ethnicity and sex due to differences in biology, the prevalence of cardiovascular risk factors, and the use and effectiveness of AF treatments. We aimed to characterize patterns of cardiovascular risk across subgroups of AF patients by sex and race/ethnicity, since doing so may provide opportunities to identify interventions. We also evaluated whether these patterns changed over time.
methodsWe utilized administrative claims data from the Optum Clinformatics® Datamart database from 2009 to 2015. Patients with AF with ≥6 months of enrollment prior to the first non-valvular AF diagnosis were included in the analysis. Final analysis utilized Cox proportional hazard models to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for cardiovascular outcomes stratified by sex and race/ethnicity. An additional analysis stratified outcomes by calendar year of AF diagnosis to evaluate changes in outcomes over time.
resultsIn a cohort of 380,636 AF patients, women had a higher risk of ischemic stroke [HR (95% CI): 1.25 (1.19, 1.31)] and lower risk of heart failure and myocardial infarction [HR (95% CI): 0.91 (0.88, 0.94) and 0.81 (0.77, 0.86), respectively)] compared to men. Black patients had elevated risk across all endpoints compared to whites, while Hispanics and Asian Americans showed no significant differences in any outcome compared to white patients. These sex and race/ethnic differences did not change over time.
conclusionsWe found sex and race/ethnic differences in risk of cardiovascular outcomes among AF patients, without evidence of improvement over time.
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