ArticlePLoS biology2019
Strong preference for autaptic self-connectivity of neocortical PV interneurons facilitates their tuning to γ-oscillations.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- DNMT1 function in cortical PV interneurons modulates cortical network activity, mood disorder‑related behavior, and perineuronal nets.Communications biology · 2026Article
- Translatable electrophysiological and behavioral abnormalities in a humanized model of SYNGAP1-disorder.Molecular psychiatry · 2026Article
- Preliminary clinical and electrophysiological findings of NAc/ALIC deep brain stimulation strategy for treatment-resistant depression.iScience · 2026Article
- Limit-Cycle Proliferation Under Parametric Delayed Feedback in a Conductance-Based Neuron: Bifurcation Landscape, Orbit Catalog, and Capacity Analysis.Entropy (Basel, Switzerland) · 2026Article
- Dual platform spatial transcriptomics reveals parvalbumin interneuron subtype vulnerability in mouse models of Alzheimer's disease.Nature communications · 2026Article
- Braking Parkinson's progression: the hypothetical druggable role of striatal parvalbumin interneurons.NPJ Parkinson's disease · 2026Review
- Transient juvenile demyelination impairs maturation and function of parvalbumin-positive interneurons in the prefrontal cortex.PLoS biology · 2025Article
- Article
- Realistic Subject-Specific Simulation of Resting State Scalp EEG Based on Physiological Model.Brain topography · 2025Article
- Oxidative Stress-mediated Loss of Hippocampal Parvalbumin Interneurons Contributes to Memory Precision Decline After Acute Sleep Deprivation.Molecular neurobiology · 2025Article
- Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review.Translational psychiatry · 2025Review
- Localization of the epileptogenic network from scalp EEG using a patient-specific whole-brain model.Network neuroscience (Cambridge, Mass.) · 2025Article
- Transition to seizure in focal epilepsy: From SEEG phenomenology to underlying mechanisms.Epilepsia · 2024Article
- Parvalbumin interneuron deficits in schizophrenia.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024Review
- The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- Physiological features of parvalbumin-expressing GABAergic interneurons contributing to high-frequency oscillations in the cerebral cortex.Current research in neurobiology · 2024Review
- Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease.Molecular psychiatry · 2023Review
- Influence of inhibitory autapses on synchronization of inhibitory network gamma oscillations.Cognitive neurodynamics · 2023Article
- Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons.Neuroscience bulletin · 2023Article
- Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Parvalbumin (PV)-positive interneurons modulate cortical activity through highly specialized connectivity patterns onto excitatory pyramidal neurons (PNs) and other inhibitory cells. PV cells are autoconnected through powerful autapses, but the contribution of this form of fast disinhibition to cortical function is unknown. We found that autaptic transmission represents the most powerful inhibitory input of PV cells in neocortical layer V. Autaptic strength was greater than synaptic strength onto PNs as a result of a larger quantal size, whereas autaptic and heterosynaptic PV-PV synapses differed in the number of release sites. Overall, single-axon autaptic transmission contributed to approximately 40% of the global inhibition (mostly perisomatic) that PV interneurons received. The strength of autaptic transmission modulated the coupling of PV-cell firing with optogenetically induced γ-oscillations, preventing high-frequency bursts of spikes. Autaptic self-inhibition represents an exceptionally large and fast disinhibitory mechanism, favoring synchronization of PV-cell firing during cognitive-relevant cortical network activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.