Evidence map›Paper›PMID 31483653›Full record

ArticleThe journal of physical chemistry. B2019

Breaking the Backbone: Central Arginine Residues Induce Membrane Exit and Helix Distortions within a Dynamic Membrane Peptide.

Matthew J McKay, Riqiang Fu, Denise V Greathouse, Roger E Koeppe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew J McKayDepartment of Chemistry and Biochemistry , University of Arkansas , Fayetteville , Arkansas 72701 , United States.ORCID 0000-0002-3079-9189
Riqiang FuNational High Magnetic Field Laboratory, Florida State University , Tallahassee , Florida 32310 , United States.ORCID 0000-0003-0075-0410
Denise V GreathouseDepartment of Chemistry and Biochemistry , University of Arkansas , Fayetteville , Arkansas 72701 , United States.ORCID 0000-0001-7104-8499
Roger E KoeppeDepartment of Chemistry and Biochemistry , University of Arkansas , Fayetteville , Arkansas 72701 , United States.ORCID 0000-0003-0676-6413

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P20 GM103429NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Transmembrane domains of membrane proteins sometimes contain conserved charged or ionizable residues which may be essential for protein function and regulation. This work examines the molecular interactions of single Arg residues within a highly dynamic transmembrane peptide helix. To this end, we have modified the GW

Indexed as

Molecular Dynamics SimulationAmino Acid SequenceArginineLipid BilayersMembrane ProteinsNuclear Magnetic Resonance, BiomolecularProtein Conformation, alpha-HelicalTryptophanArginineLipid BilayersMembrane ProteinsTryptophan

Identifiers

PMID31483653
PMCPMC6765365

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.