ReviewJournal of leukocyte biology2019
Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.
Review in Journal of leukocyte biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Maternal obesity and the risk of neonatal sepsis: a meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Maternal prenatal infection and childhood leukaemia: a Childhood Cancer and Leukemia International Consortium (CLIC) meta-analysis.International journal of epidemiology · 2025Pooled it
- Epigenetics and childhood obesity: DNA methylation coordinates environment and gene regulation.Endocrine reviews · 2026Review
- Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine · 2026Article
- Sex-dependent phenotypes of anxiety and palatable food-seeking in offspring born from rats exposed to a high-fat diet.Frontiers in psychology · 2026Article
- Maternal Diet-Induced Excess Adiposity in Mice Disrupts Mid-Gestation Decidual Immune and Vascular Homeostasis Without Impairing Spiral Artery Remodeling.Acta physiologica (Oxford, England) · 2025Article
- Article
- Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity.Frontiers in hematology · 2025Article
- Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring.International journal of molecular sciences · 2024Review
- Maternal prepregnancy overweight/obesity increase the risk of low Apgar scores in twins: a population-based cohort study in China.Frontiers in pediatrics · 2024Article
- Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases.Nutrients · 2023Article
- Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity.Cell reports · 2023Article
- Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders.Metabolites · 2023Review
- Article
- Maternal imprinting and determinants of neonates' immune function in the SEPAGES mother-child cohort.Frontiers in immunology · 2023Article
- Role of Obesity in Female Reproduction.International journal of medical sciences · 2023Review
- Survival analysis based on body mass index in patients with Covid-19 admitted to the intensive care unit of Amir Al-Momenin Hospital in Arak - 2021.Obesity medicine · 2022Article
- Translational Utility of the Nonhuman Primate Model.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Nonhuman Primates in Translational Research.Annual review of animal biosciences · 2022Review
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Maternal pregravid obesity results in several adverse health outcomes during pregnancy, including increased risk of gestational diabetes, preeclampsia, placental abruption, and complications at delivery. Additionally, pregravid obesity and in utero exposure to high fat diet have been shown to have detrimental effects on fetal programming, predisposing the offspring to adverse cardiometabolic, endocrine, and neurodevelopmental outcomes. More recently, a deeper appreciation for the modulation of offspring immunity and infectious disease-related outcomes by maternal pregravid obesity has emerged. This review will describe currently available animal models for studying the impact of maternal pregravid obesity on fetal immunity and review the data from clinical and animal model studies. We also examine the burden of pregravid obesity on the maternal-fetal interface and the link between placental and systemic inflammation. Finally, we discuss future studies needed to identify key mechanistic underpinnings that link maternal inflammatory changes and fetal cellular reprogramming events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.