Evidence map›Paper›PMID 31483418›Full record

ArticleMetallomics : integrated biometal science2019

Activated zinc transporter ZIP7 as an indicator of anti-hormone resistance in breast cancer.

Silvia Ziliotto, Julia M W Gee, Ian O Ellis, Andrew R Green, Pauline Finlay, Anna Gobbato, Kathryn M Taylor

Open access · hybridAbstract read
In one paragraph

Article in Metallomics : integrated biometal science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Current oncology (Toronto, Ont.) · 2026
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  9. Delineating Zinc Influx Mechanisms during Platelet Activation.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Silvia ZiliottoBreast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk.ORCID 0000-0002-7661-4477
Julia M W GeeBreast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk.
Ian O EllisNottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK.
Andrew R GreenNottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, Nottingham, UK.
Pauline FinlayBreast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk.
Anna GobbatoBreast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk.
Kathryn M TaylorBreast Cancer Molecular Pharmacology Unit, School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK. taylorkm@cardiff.ac.uk.ORCID 0000-0002-9576-9490
Cardiff University · GBUniversity of Nottingham · GB

Funding

Wellcome TrustWellcome Trust 091991/Z/10/Z
6 · The paper itself

Abstract

ZIP7, a member of the ZIP family of zinc importers, resides on the endoplasmic reticulum membrane and transports zinc from intracellular stores to the cytoplasm after activation by CK2 phosphorylation on two serine residues (S275 and S276). ZIP7 is known to be required for the growth of anti-hormone resistant breast cancer models, especially those with acquired tamoxifen resistance developed from MCF-7. Using our new pS

Indexed as

Antineoplastic Agents, HormonalBreast NeoplasmsCation Transport ProteinsDrug Resistance, NeoplasmFemaleHumansMCF-7 CellsProto-Oncogene MasTamoxifenZincAntineoplastic Agents, HormonalCation Transport ProteinsMAS1 protein, humanProto-Oncogene MasSLC39A7 protein, humanTamoxifenZinc

Identifiers

PMID31483418
PMCPMC6796783
OpenAlexW2971495274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.