ArticleArchives of endocrinology and metabolism2019
Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America.
Article in Archives of endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06653257 (Outcomes of a 5-Year Active Surveillance Program in Bethesda IV-VI Thyroid Nodules), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Outcomes of a 5-Year Active Surveillance Program in Bethesda IV-VI Thyroid Nodules
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- 2025 Korean Thyroid Association Clinical Management Guideline on Active Surveillance for Low-Risk Papillary Thyroid Carcinoma.Endocrinology and metabolism (Seoul, Korea) · 2025Guideline
- Size Increment During Surveillance in Papillary Thyroid Cancer: Evidence Synthesis and Dose-Response Meta-Analysis.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Outcomes and effectiveness of active surveillance for low-risk papillary thyroid carcinoma: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Observational
- Active Surveillance of Papillary Thyroid Cancer-A Feasibility Experience from a Tertiary Care Centre.Indian journal of surgical oncology · 2025Article
- Standardized Ultrasound Evaluation for Active Surveillance of Low-Risk Thyroid Microcarcinoma in Adults: 2024 Korean Society of Thyroid Radiology Consensus Statement.Journal of the Korean Society of Radiology · 2024Review
- Standardized Ultrasound Evaluation for Active Surveillance of Low-Risk Thyroid Microcarcinoma in Adults: 2024 Korean Society of Thyroid Radiology Consensus Statement.Korean journal of radiology · 2024Article
- Impact of a simple informative leaflet on Brazilian doctors' attitudes towards active surveillance of thyroid microcarcinomas.Heliyon · 2024Article
- Cervical lymph node metastases in patients with differentiated thyroid cancer: A new (and more relevant) indication of active surveillance?Archives of endocrinology and metabolism · 2024Article
- Decision Regret Following the Choice of Surgery or Active Surveillance for Small, Low-Risk Papillary Thyroid Cancer: A Prospective Cohort Study.Thyroid : official journal of the American Thyroid Association · 2024Observational
- Thirty years of active surveillance for low-risk thyroid cancer, lessons learned and future directions.Reviews in endocrine & metabolic disorders · 2024Review
- Dynamic risk assessment in patients with differentiated thyroid cancer.Reviews in endocrine & metabolic disorders · 2024Review
- Active Surveillance for Low-Risk Thyroid Cancers: A Review of Current Practice Guidelines.Endocrinology and metabolism (Seoul, Korea) · 2024Review
- Active surveillance of papillary thyroid carcinoma in Latin America: a scoping review.Archives of endocrinology and metabolism · 2024Article
- Implementing active surveillance for low-risk thyroid carcinoma into clinical practice: collaborative recommendations for Latin America.Archives of endocrinology and metabolism · 2024Review
- Conservative management of low-risk papillary thyroid carcinoma: a review of the active surveillance experience.Thyroid research · 2023Review
- Invasion of a Recurrent Laryngeal Nerve from Small Well-Differentiated Papillary Thyroid Cancers: Patient Selection Implications for Active Surveillance.Thyroid : official journal of the American Thyroid Association · 2022Article
- Assessing mPTC Progression during Active Surveillance: Volume or Diameter Increase?Journal of clinical medicine · 2021Article
- Active surveillance in small cytological indeterminate thyroid nodules: a call to common sense?Endocrine · 2021Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the percentage of patients with papillary thyroid carcinoma (PTC) who accepted active surveillance as an alternative to surgery in our clinical practice and to describe the clinical characteristics and outcomes of patients with Bethesda category V and VI thyroid nodules who chose active surveillance. SUBJECTS AND
methodsWe included 136 PTC patients from the Hospital de Clínicas, University of Buenos Aires without (i) US extrathyroidal extension, (ii) tumors adjacent to the recurrent laryngeal nerve or trachea, and/or (iii) US regional lymph-node metastasis or clinical distant metastasis. PTC progression was defined as the presence of i) a tumor larger than ≥ 3 mm, ii) novel appearance of lymph-node metastasis, and iii) serum thyroglobulin doubling time in less than one year. For patients with these features, surgery was recommended.
resultsOnly 34 (25%) of 136 patients eligible for active surveillance accepted this approach, and around 10% of those who accepted abandoned it due to anxiety. The frequency of patients with tumor enlargement was 17% after a median of 4.6 years of follow-up without any evidence of nodal or distant metastases. Ten patients who underwent surgical treatment after a median time of 4 years of active surveillance (AS) had no evidence of disease after a median of 3.8 years of follow-up after surgery.
conclusionAlthough not easily accepted in our cohort of patients, AS would be safe and easily applicable in experienced centers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.