Evidence map›Paper›PMID 31482844›Full record

ArticleeLife2019

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.

Ke-Xin Li, Mu He, Wenlei Ye, Jeffrey Simms, Michael Gill, Xuaner Xiang, Yuh Nung Jan, Lily Yeh Jan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Anoctamin 2 deletion alters dopamine-related signaling and impairs inhibitory behavioral control in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Review
  3. Article
  4. Novel voltage-dependent ClNeuroscience letters · 2025
    Article
  5. Article
  6. Review
  7. The Slack Channel Regulates Anxiety-Like Behaviors via Basolateral Amygdala Glutamatergic Projections to Ventral Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  8. Article
  9. KScientific reports · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ke-Xin LiDepartment of Physiology, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-3879-294X
Mu HeDepartment of Physiology, University of California, San Francisco, San Francisco, United States.
Wenlei YeDepartment of Physiology, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-4694-1493
Jeffrey SimmsGladstone Institute of Neurological Disease, San Francisco, United States.
Michael GillGladstone Institute of Neurological Disease, San Francisco, United States.
Xuaner XiangDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, United States.
Yuh Nung JanDepartment of Physiology, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-1367-6299
Lily Yeh JanDepartment of Physiology, University of California, San Francisco, San Francisco, United States.ORCID 0000-0003-3938-8498
Howard Hughes Medical Institute · USGladstone Institutes · USUniversity of California, San Francisco · US

Funding

Molecular, Genetic & Physiological Studies of Calcium-activated Chloride ChannelsR01NS069229 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, LILY Y · 2011 to 2020
$3.5M
Ion channels as mechanic modulators of epithelial tissue homeostasisF32HD089639 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HE, MU · 2017 to 2019
$190k
Eunice Kennedy Shriver National Institute of Child Health and Human Development F32HD089639National Institute for Health Research RO1 NS069229NICHD NIH HHS F32 HD089639NINDS NIH HHS R01 NS069229
6 · The paper itself

Abstract

TMEM16B (ANO2) is the Ca

Indexed as

AnxietySignal TransductionAmygdalaAnimalsAnoctaminsBehavior, AnimalGABAergic NeuronsMice, KnockoutANO2 protein, mouseAnoctaminsanxietycalcium activated chloride channels (CaCC)fearGABAergic transmissionmouseneuroscienceTMEM16B (ANO2)

Identifiers

PMID31482844
PMCPMC6746550
OpenAlexW2971461433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.