ArticleAngewandte Chemie (International ed. in English)2019
A General Acid-Mediated Hydroaminomethylation of Unactivated Alkenes and Alkynes.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Stereoselective Synthesis of Aminals Through Enzyme-Catalyzed Intermolecular C(spAngewandte Chemie (International ed. in English) · 2026Article
- Eschenmoser's salts: from design to applications in organic synthesis.Organic chemistry frontiers : an international journal of organic chemistry · 2026Review
- Unified Synthesis of Unconventional α-Polyhalogenated Amines Through Hydroaminoalkylation.Angewandte Chemie (International ed. in English) · 2026Article
- An alkyl-swap platform for late-stage modification of secondary N-methylamines.Nature chemistry · 2026Article
- Dialkylaminoalkylation of β-ketosulfones via ring-opening of 3-sulfonylpyrrolidines.Beilstein journal of organic chemistry · 2026Article
- Facile (Z)-Selective Synthesis of β,γ-Unsaturated Ketones by a Silicon-based Olefination Strategy.Angewandte Chemie (International ed. in English) · 2025Article
- Hexafluoroisopropanol-Mediated Cascade Cyclization for Construction of α‑Amino-γ-spirolactones.JACS Au · 2025Article
- Cu-Catalyzed Three-Component Carbofunctionalization of 1,3-Dienes.ACS catalysis · 2025Article
- Iodide Anion Enables a Reductive Cross-Electrophile Coupling for Preparing Tertiary Amines.Angewandte Chemie (International ed. in English) · 2025Article
- Preparation of Aminals under Continuous Flow Conditions.Journal of chemical education · 2023Article
- General acid-mediated aminolactone formation using unactivated alkenes.Chemical science · 2023Article
- The Eschenmoser's Salt as a Formylation Agent for the Synthesis of Indolizinecarbaldehydes and Their Use for Colorimetric Nitrite Detection.Angewandte Chemie (International ed. in English) · 2023Article
- Nutzung von elektronenarmen Iminiumintermediaten zur Synthese von wertvollen Aminen.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Article
- Leveraging Electron-Deficient Iminium Intermediates in a General Synthesis of Valuable Amines.Angewandte Chemie (International ed. in English) · 2022Article
- HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser's salt.Angewandte Chemie (International ed. in English) · 2022Article
- A Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines.Angewandte Chemie (International ed. in English) · 2022Article
- Enantioselective Synthesis of α-Aryl-βAngewandte Chemie (International ed. in English) · 2021Article
- Desaturation via Redox-Neutral Hydrogen Transfer Process: Synthesis of 2-Allyl Anilines, Mechanism and Applications.iScience · 2020Article
- Palladium-catalyzed hydroalkylation of methylenecyclopropanes with simple hydrazones.Chemical science · 2020Article
- Redox-Annulations of Cyclic Amines withOrganic letters · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In comparison to the extensively studied metal-catalyzed hydroamination reaction, hydroaminomethylation has received significantly less attention despite its considerable potential to streamline amine synthesis. State-of-the-art protocols for hydroaminomethylation of alkenes rely largely on transition-metal catalysis, enabling this transformation only under highly designed and controlled conditions. Here we report a broadly applicable, acid-mediated approach to the hydroaminomethylation of unactivated alkenes and alkynes. This methodology employs cheap, readily available, and bench-stable reactants and affords the desired amines with excellent functional group tolerance and impeccable regioselectivity. The broad scope of this transformation, as well as mechanistic investigations and in situ domino functionalization reactions are reported.
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