Evidence map›Paper›PMID 31482518›Full record

ArticleDrug delivery and translational research2020

A simple and low-energy method to prepare loratadine nanosuspensions for oral bioavailability improvement: preparation, characterization, and in vivo evaluation.

Dandan Yang, Ruirui Li, Fang Zhang, Li Qin, Feifei Peng, Shanshan Jiang, Huiyang He, Xiumei Lu, Peng Zhang

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dandan YangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Ruirui LiSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Fang ZhangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Li QinSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Feifei PengSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Shanshan JiangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Huiyang HeSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Xiumei LuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Peng ZhangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China. zhangpenglab@163.com.ORCID 0000-0002-6881-9800
Shenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effervescent method, as a simple and effective technology to prepare nanosuspensions, has gained great attention. In this present research, loratadine (LTD) nanosuspensions were successfully prepared by the effervescent method using Soluplus as stabilizer to improve the bioavailability of LTD in vivo. The mean particle size was about 100 nm. And the LTD nanosuspensions were lyophilized for further study. The freeze-dried powders could be dissolved quickly, and the mean particle size remained almost unchanged after powders were re-dissolved. By transmission electron microscope (TEM), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and X-ray diffraction (X-RD), the characterizations of LTD nanosuspensions and freeze-dried powders were studied. Commercial tablets were used as the reference to investigate the dissolution behaviors in different release media and of bioavailability in vivo of LTD freeze-dried powders. The cumulative dissolution of the LTD freeze-dried powders was superior in different release media compared with commercial tables. In addition, for the evaluation of the bioavailability of LTD nanosuspensions, the LTD concentration in rat plasma was determined using LC-MS/MS method. The results showed that the AUC

Indexed as

Administration, OralAnimalsBiological AvailabilityDrug CompoundingFreeze DryingLoratadineMaleNanoparticlesParticle SizePlasmaPolyethylene GlycolsPolyvinylsRatsSuspensionsTabletsLoratadinePolyethylene Glycolspolyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymerPolyvinylsSuspensionsTabletsBioavailabilityEffervescent methodLoratadineNanosuspensions

Identifiers

PMID31482518
OpenAlexW2972244663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.