ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019
Factors associated with quality of life in systemic sclerosis: a cross-sectional study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06425653 (The Effect of Exercise Program Applied to Patients With Scleroderma on Functional Outcomes), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Exercise Program Applied to Patients With Scleroderma on Functional Outcomes: A Randomized Controlled Trial
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies.BMC oral health · 2021Pooled it
- Is rituximab effective for systemic sclerosis? A systematic review and meta-analysis.Advances in rheumatology (London, England) · 2021Pooled it
- Understanding patient-reported disease burden in systemic sclerosis: key clinical and demographic features revealed by the EULAR Systemic Sclerosis Impact of Disease (ScleroID) Questionnaire.EULAR rheumatology open · 2026Article
- Capillaroscopic patterns are associated with interstitial lung disease, skin fibrosis, anti-Th/To antibodies and quality of life in systemic sclerosis: a prospective cross-sectional study.Frontiers in medicine · 2026Article
- [S2k guidelines on diagnostics and treatment of systemic sclerosis : Full version].Zeitschrift fur Rheumatologie · 2025Review
- Orofacial Manifestation of Systemic Sclerosis: A Cross-Sectional Study and Future Prospects of Oral Capillaroscopy.Diagnostics (Basel, Switzerland) · 2024Article
- Psychological impact of autologous hematopoietic stem cell transplantation in systemic sclerosis patients and influence of resilience.Frontiers in immunology · 2024Article
- Psychometric analysis and validation of the Persian translation of the systemic sclerosis questionnaire (SySQ).Journal of education and health promotion · 2024Article
- Determinants of Depressive Symptoms, Quality of Life, Subjective Health Status and Physical Limitation in Patients with Systemic Sclerosis.Acta dermato-venereologica · 2023Article
- Systemic Sclerosis Quality of Life Questionnaire (SScQoL): translation into Turkish and assessing its psychometric properties.Clinical rheumatology · 2023Article
- Factors associated with life satisfaction in systemic sclerosis: Examining the moderating roles of social support and spiritual well-being.Journal of scleroderma and related disorders · 2023Article
- Patient Assessment Chronic Illness Care (PACIC) and its associations with quality of life among Swiss patients with systemic sclerosis: a mixed methods study.Orphanet journal of rare diseases · 2023Article
- Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic.Frontiers in integrative neuroscience · 2023Article
- The effect of a self-management program on the quality of life of patients with scleroderma.Journal of education and health promotion · 2023Article
- Functional disability and health-related quality of life among systemic sclerosis patients in Bangladesh.BMC rheumatology · 2022Article
- Gastric antral vascular ectasia in systemic sclerosis: a study of its epidemiology, disease characteristics and impact on survival.Arthritis research & therapy · 2022Article
- Dysphagia, reflux and related sequelae due to altered physiology in scleroderma.World journal of gastroenterology · 2021Review
- Fatigue Predicts Future Reduced Social Participation, not Reduced Physical Function or Quality of Life in People with Systemic Sclerosis.Journal of scleroderma and related disorders · 2021Article
- Transcriptome analysis of human dermal fibroblasts following red light phototherapy.Scientific reports · 2021Article
- Cultural adaptation and validation of the Systemic Sclerosis Quality of Life questionnaire into Arabic language.Clinical rheumatology · 2021Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 2 countries.
Funding
Abstract
introductionSystemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs, leading to their failure and disturbances in the morphology and function of blood vessels. The disease affects people in different ways, and identifying how the difficulties and limitations are related to quality of life may contribute to designing helpful interventions. The aim of this study was to identify factors associated with quality of life in people with SSc.
methodsThis was a cross-sectional study conducted in 11 rheumatic centres in Poland. Patients diagnosed with SSc were included. Quality of life was measured using the SSc Quality of Life Questionnaire (SScQoL). The following candidate factors were entered in preliminary multivariable analysis: age, place of residence, marital status, occupational status, disease type, disease duration, pain, fatigue, intestinal problems, breathing problems, Raynaud's symptoms, finger ulcerations, disease severity, functional disability, anxiety and depression. Factors that achieved statistical significance at the 10% level were then entered into a final multivariable model. Factors achieving statistical significance at the 5% level in the final model were considered to be associated with quality of life in SSc.
resultsIn total, 231 participants were included. Mean age (SD) was 55.82 (12.55) years, disease duration 8.39 (8.18) years and 198 (85.7%) were women. Factors associated with quality of life in SSc were functional disability (β = 2.854, p < 0.001) and anxiety (β = 0.404, p < 0.001). This model with two factors (functional disability and anxiety) explained 56.7% of the variance in patients with diffuse SSc and 73.2% in those with localized SSc.
conclusionsFunctional disability and anxiety are significantly associated with quality of life in SSc. Interventions aimed at improving either of these factors may contribute towards improving the quality of life of people with SSc.
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