Evidence map›Paper›PMID 31482406›Full record

Observational studyJournal of gastrointestinal cancer2020

Assessment of Serum MicroRNA-21 Gene Expression for Diagnosis and Prognosis of Colorectal Cancer.

Amal F Ghareib, Randa H Mohamed, Ahmed R Abd El-Fatah, Sara F Saadawy

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of gastrointestinal cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amal F GhareibMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Randa H MohamedMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. randahussiny@yahoo.com.ORCID http://orcid.org/0000-0003-2983-9232
Ahmed R Abd El-FatahGeneral Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sara F SaadawyMedical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroRNAs (miRNAs) are small, non-coding RNAs that are involved in carcinogenesis through posttranscriptional gene regulatory activity. The current study aimed to evaluate serum miR-21 expression levels as potential biomarkers for diagnosis and prognosis of colorectal cancer (CRC) patients.

methodsQuantitative real-time RT-PCR was applied to determine the relative expression level of miR-21 in serum. At the same time, the sensitivity and specificity of this marker were evaluated by receiver operating characteristic (ROC) curve analysis.

resultsmiR-21 expression levels of serum were 3.4 and 1.25 in patient and control, respectively (p < 0.05). The sensitivity and specificity of miR-21 were found to be 95.8% and 91.7%, respectively. The high expression level of serum miR-21 were associated with higher local recurrence, TNM staging, PT staging, venous invasion, liver metastasis, and recurrence (p < 0.05).

conclusionThe results of this study indicated that miR-21 expression levels in serum can be considered as a novel non-invasive biomarker for early detection and prognosis of CRC patients.

Indexed as

Biomarkers, TumorCase-Control StudiesColorectal NeoplasmsEarly Detection of CancerFemaleGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMaleMicroRNAsMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisReal-Time Polymerase Chain ReactionBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanColorectal cancerDiagnosisExpressionsmiR-21Prognosis

Identifiers

PMID31482406

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.