Evidence map›Paper›PMID 31482401›Full record

ArticleMolecular neurobiology2020

MicroRNA-34a Regulates the Depression-like Behavior in Mice by Modulating the Expression of Target Genes in the Dorsal Raphè.

Luisa Lo Iacono, Donald Ielpo, Alessandra Accoto, Matteo Di Segni, Lucy Babicola, Sebastian Luca D'Addario, Fabio Ferlazzo, Tiziana Pascucci, Rossella Ventura, Diego Andolina

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. GABAergic miR-34a regulates Dorsal Raphè inhibitory transmission in response to aversive, but not rewarding, stimuli.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. The Role of MicroRNA and Microbiota in Depression and Anxiety.Frontiers in behavioral neuroscience · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Luisa Lo IaconoDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Donald IelpoDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Alessandra AccotoDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Matteo Di SegniDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Lucy BabicolaDepartment of Applied and Biotechnological Clinical Sciences, University of L'Aquila, 67010, L'Aquila, Italy.
Sebastian Luca D'AddarioDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Fabio FerlazzoDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Tiziana PascucciDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy.
Rossella VenturaDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy. rossella.ventura@uniroma1.it.
Diego AndolinaDepartment of Psychology, Sapienza University, Via Dei Marsi, 78, 00184, Rome, Italy. diego.andolina@uniroma1.it.ORCID http://orcid.org/0000-0002-9143-858X
Fondazione Santa Lucia · ITSapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (IT) RBSI14G1HH
6 · The paper itself

Abstract

Chronic stress exposure is known to increase vulnerability to the expression of psychiatric disorders, such as depression. Clinical and preclinical evidences support the involvement of the microRNA-34 family in stress-related psychiatric conditions and in the regulation of stress responses. However, the mechanism and the multiple targets by which the microRNA-34 family can affect the stress response and stress-related behavioral alteration are not fully known. Here, with the aid of constitutive and conditional genetic strategy, we examined the role of microRNA-34 family in the expression of depression-like phenotype in mice induced by chronic stress exposure, and we identified their "in vivo" targets during the stressful challenge. We found that microRNA-34a, under chronic stress, is significantly up-regulated in the mouse raphe nuclei, where its recruitment is necessary to induce depression-like behavioral alterations and impact the function of the serotonergic system. Moreover, by next-generation RNA-seq of Ago-2-bound mRNAs, we identified genes that are targeted by microRNA-34a in response to chronic stress and that are likely to mediate its effects.

Indexed as

Behavior, AnimalGene Expression RegulationAnimalsChronic DiseaseDepressionDorsal Raphe NucleusGene DeletionMice, KnockoutMicroRNAsRNA-Induced Silencing ComplexStress, PsychologicalUp-RegulationMicroRNAsMIRN34a microRNA, mouseRNA-Induced Silencing ComplexAgo2, RISC-SeqChronic stressDepression-like behaviorMicroRNA-34Raphe nucleiSerotonin

Identifiers

PMID31482401
OpenAlexW2971763632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.