ArticleSurgical endoscopy2020
The effect of anticoagulants on delayed bleeding after colorectal endoscopic submucosal dissection.
Article in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
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- Prevention of Delayed Bleeding after Endoscopic Resection using Gel Hemostatic Powder: A Multicentric Open-lapel Prospective Study.Endoscopy international open · 2026Article
- Defect closure after endoscopic submucosal dissection decreased the adverse events in patients with large rectal neoplasms: a propensity score matching analysis.Surgical endoscopy · 2025Article
- Safety of edoxaban for delayed bleeding in gastrointestinal endoscopic procedures with a high risk of bleeding.DEN open · 2025Article
- Establishing a nomogram for predicting the risk factors for delayed bleeding after endoscopic submucosal dissection for colorectal tumors.International journal of colorectal disease · 2024Article
- International Digestive Endoscopy Network Consensus on the Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy.Gut and liver · 2024Review
- [IDEN Consensus on Management of Antithrombotic Agents in Patients Undergoing Gastrointestinal Endoscopy].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Review
- The Management of Direct Oral Anticoagulants for Colorectal Endoscopic Submucosal Dissection: A Multicenter Observational Study.Digestive diseases and sciences · 2024Observational
- International Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy.Clinical endoscopy · 2024Review
- Complications after endoscopic submucosal dissection for early colorectal cancer (Review).Oncology letters · 2023Review
- Assessment of delayed bleeding after endoscopic submucosal dissection of early-stage gastrointestinal tumors in patients receiving direct oral anticoagulants.World journal of gastroenterology · 2023Review
- [Research Progress in Delayed Bleeding after Endoscopic Submucosal Dissection of Early-Stage Gastrointestinal Cancer].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Self-completion method of endoscopic submucosal dissection using the Endosaber for treating colorectal neoplasms (with video).Scientific reports · 2022Article
- Bleeding After Gastric Endoscopic Submucosal Dissection Focused on Management of Xa Inhibitors.Journal of gastric cancer · 2022Article
- Management of anticoagulants in delayed bleeding after endoscopic resection: A systematic review and meta-analysis.Endoscopy international open · 2021Article
- Risk of Bleeding after Colorectal Endoscopic Resection in Patients with Continued Warfarin Use Compared to Heparin Replacement: A Propensity Score Matching Analysis.Gastroenterology research and practice · 2021Article
- Anticoagulation and antiplatelet management in gastrointestinal endoscopy: A review of current evidence.World journal of gastrointestinal endoscopy · 2020Review
- Effect of anticoagulants on the risk of delayed bleeding after colorectal endoscopic submucosal dissection.Endoscopy international open · 2020Article
- Safety of cholecystectomy in patients under antithrombotic Drugs: A systematic review and meta-analysis.Pakistan journal of medical sciencesReview
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe withdrawal of antithrombotic therapy from patients at high risk of thromboembolism is controversial. Previously, treatment with anticoagulants, such as warfarin and dabigatran, was recommended for heparin bridge therapy (HBT) during endoscopic submucosal dissection (ESD). However, HBT is associated with a high risk of bleeding during and after ESD. This study aimed to investigate the clinical outcomes of colorectal ESD in patients treated with warfarin and direct oral anticoagulants (DOAC).
methodsThis study included 412 patients with superficial colorectal neoplasms that were resected by ESD between June 2010 and June 2018. The patients were classified into two groups: without antithrombotics (n = 286) and with anticoagulants (n = 51). The anticoagulants group was further divided into two groups: warfarin (n = 26) and DOAC (n = 25).
resultsAmong all patients, delayed bleeding occurred in 35 (8.5% [35/412]) patients. The bleeding rate in the anticoagulants group (11.8% [6/51]) was higher than that in the group without antithrombotics (6.6% [19/286]), but the difference was not statistically significant (P = 0.240). The bleeding rate in the DOAC group (16.0% [4/25]) was higher than that in the warfarin group (7.7% [2/26]), but the difference was not statistically significant (P = 0.419). All delayed bleeding was successfully managed with endoscopic hemostasis. Thromboembolic events were not observed in any patients.
conclusionsThe bleeding rate with anticoagulants was relatively high. However, all bleeding events with anticoagulants were minor and clinically controllable. Colorectal ESD with DOAC and warfarin may be feasible and acceptable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.