Evidence map›Paper›PMID 31482222›Full record

ArticleIntensive care medicine2019

Mental illness after admission to an intensive care unit.

Lavarnan Sivanathan, Hannah Wunsch, Simone Vigod, Andrea Hill, Ruxandra Pinto, Damon C Scales

Abstract read
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In one paragraph

Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Observational
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  6. Prevalence and long-term outcomes of patients with life-limiting illness admitted to intensive care units in Australia and New Zealand.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lavarnan SivanathanInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. L.Sivanathan@utoronto.ca.ORCID http://orcid.org/0000-0001-9100-5648
Hannah WunschInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Simone VigodInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Andrea HillDepartment of Critical Care Medicine, Sunnybrook Hospital, Toronto, ON, Canada.
Ruxandra PintoDepartment of Critical Care Medicine, Sunnybrook Hospital, Toronto, ON, Canada.
Damon C ScalesInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Funding

Ministry of Health Ontario Na
6 · The paper itself

Abstract

purposeSurvivors of critical illness may be at higher risk of developing subsequent mental illness. We sought to determine the risk of new mental illness diagnoses across a large population of intensive care unit (ICU) survivors compared with hospitalized patients.

methodsPopulation-based study (2005-2015) conducted in adults hospitalized in Ontario, Canada. The primary exposure was ICU admission for ≥ 48 h; secondary exposures were ICU procedures including mechanical ventilation and duration of ICU. The primary outcome was mental illness diagnosed during the year after hospital discharge. To account for case mix differences between ICU and other hospitalized patients, sensitivity analyses were conducted restricting to six pre-specified diagnoses that can lead to hospitalization with or without ICU.

results1,847,462 patients survived hospitalization, of whom 121,101 were admitted to ICU for ≥ 48 h. ICU patients had a higher rate of new mental illness diagnoses in the year after discharge compared to hospitalized patients (17 vs. 15%, adjusted hazard ratio (aHR) 1.08, 95% CI 1.07-1.10). In analyses restricted to pre-specified most responsible diagnoses, the increased risk associated with ICU was only significant for patients with pneumonia. Among ICU survivors, exposure to mechanical ventilation (aHR: 1.08; 95% CI 1.05-1.12) or longer ICU stays (aHR: 1.004 per day; 95% CI 1.003-1.005) increased the risk of new mental illness diagnosis.

conclusionsICU was associated with a marginally increased risk of mental illness diagnosis after hospitalization that was often no longer apparent when reason for admission was considered. Patients exposed to mechanical ventilation or longer ICU stays may be at higher risk of subsequent mental illnesses.

Indexed as

AdolescentAdultAgedAged, 80 and overCritical IllnessFemaleHospitalizationHumansIntensive Care UnitsLength of StayMaleMental DisordersMiddle AgedOntarioProportional Hazards ModelsSurvivorsAnxietyCritical illnessDepressionHospitalizationPost intensive care syndrome

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.