Evidence map›Paper›PMID 31482105›Full record

ArticleNeurophotonics2019

Speckle reduction in visible-light optical coherence tomography using scan modulation.

Ian Rubinoff, Lisa Beckmann, Yuanbo Wang, Amani A Fawzi, Xiaorong Liu, Jenna Tauber, Katie Jones, Hiroshi Ishikawa, Joel S Schuman, Roman Kuranov and 1 more

Open access · goldAbstract read
In one paragraph

Article in Neurophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Frontiers in ophthalmology · 2025
    Review
  7. Neurophotonics · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ian RubinoffNorthwestern University, Department of Biomedical Engineering, Evanston, Illinois, United States.
Lisa BeckmannNorthwestern University, Department of Biomedical Engineering, Evanston, Illinois, United States.
Yuanbo WangOpticent Health, Evanston, Illinois, United States.
Amani A FawziNorthwestern University, Department of Ophthalmology, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0002-9568-3558
Xiaorong LiuUniversity of Virginia, Department of Biology and Psychology, Charlottesville, Virginia, United States.
Jenna TauberNew York University, Department of Ophthalmology, New York, United States.ORCID https://orcid.org/0000-0002-0090-3598
Katie JonesNew York University, Department of Ophthalmology, New York, United States.
Hiroshi IshikawaNew York University, Department of Ophthalmology, New York, United States.
Joel S SchumanNew York University, Department of Ophthalmology, New York, United States.
Roman KuranovNorthwestern University, Department of Biomedical Engineering, Evanston, Illinois, United States.
Hao F ZhangNorthwestern University, Department of Biomedical Engineering, Evanston, Illinois, United States.ORCID https://orcid.org/0000-0001-5089-1196
Northwestern University · USNew York University · USUniversity of Virginia · US

Funding

Visible-light optical coherence tomography for clinical glaucoma managementR44EY026466 · NEI · OPTICENT, INC. · PI KURANOV, ROMAN · 2018 to 2023
$2.7M
Investigating oxygen metabolism in diabetic retinopathyR01EY026078 · NEI · NORTHWESTERN UNIVERSITY · PI SHEIBANI, NADER, ZHANG, HAO F · 2016 to 2020
$2.3M
Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0M
Functional Retinal Imaging to Monitor Pharmaco-Therapies in Diabetic RetinopathyDP3DK108248 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FAWZI, AMANI A, ZHANG, HAO F · 2015 to 2015
$1.9M
Mechanisms underlying the formation of the cornea and ocular surface epitheliumR01EY028304 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KUME, TSUTOMU · 2018 to 2021
$1.6M
Visual Sciences T32T32EY025202 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Gregory William Schwartz · 2015 to 2026
$1.4M
Method for accurate retinal oxygen metabolic rate extractionR43EY028475 · NEI · OPTICENT, INC. · PI WANG, YUANBO · 2017 to 2017
$225k
NEI NIH HHS R01 EY026078NEI NIH HHS R01 EY028304NEI NIH HHS R01 EY029121NEI NIH HHS R43 EY028475NEI NIH HHS R44 EY026466NEI NIH HHS T32 EY025202NIDDK NIH HHS DP3 DK108248
6 · The paper itself

Abstract

We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed

Indexed as

clinicimagingoptical coherence tomographyretinaspecklevisible light

Identifiers

PMID31482105
PMCPMC6718816
OpenAlexW2972261371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.