Evidence map›Paper›PMID 31482013›Full record

ArticleNPJ vaccines2019

Interrogation of a live-attenuated enterotoxigenic

Subhra Chakraborty, Arlo Randall, Tim J Vickers, Doug Molina, Clayton D Harro, Barbara DeNearing, Jessica Brubaker, David A Sack, A Louis Bourgeois, Philip L Felgner and 8 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Flagellar regulation in enterotoxigenicInfection and immunity · 2026
    Article
  3. Article
  4. Review
  5. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Shigella-Controlled Human Infection Models: Current and Future Perspectives.Current topics in microbiology and immunology · 2024
    Review
  12. The Controlled Human Infection Model for Enterotoxigenic Escherichia coli.Current topics in microbiology and immunology · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. The Diversity ofMicroorganisms · 2023
    Review
  18. Review
  19. Whole Genome Sequencing and CRISPR/Cas9 Gene Editing of EnterotoxigenicInternational journal of molecular sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Subhra Chakraborty1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Arlo Randall2Antigen Discovery, Inc. (ADI), Irvine, CA USA.
Tim J Vickers3Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO USA.
Doug Molina2Antigen Discovery, Inc. (ADI), Irvine, CA USA.
Clayton D Harro1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Barbara DeNearing1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Jessica Brubaker1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
David A Sack1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
A Louis Bourgeois1Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Philip L Felgner2Antigen Discovery, Inc. (ADI), Irvine, CA USA.
Xiaowu Liang2Antigen Discovery, Inc. (ADI), Irvine, CA USA.
Sachin Mani5Enteric Vaccine Initiative, PATH, Washington DC, USA.ORCID 0000-0003-2974-6853
Heather Wenzel5Enteric Vaccine Initiative, PATH, Washington DC, USA.
R Reid Townsend6Department of Medicine, Divsion of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, USA.
Petra E Gilmore6Department of Medicine, Divsion of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, USA.
Michael J DarsleyMD Biologic Consulting Ltd, Cambridge, UK.
David A Rasko8The Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD USA.
James M Fleckenstein3Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, MO USA.ORCID 0000-0002-1148-697X
Johns Hopkins University · USWashington University in St. Louis · USAntigen Discovery (United States) · USProgram for Appropriate Technology in Health · USHuman Genome Sciences (United States) · USUniversity of California, Irvine · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Novel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4M
Molecular Microbiology of Enterotoxigenic E. coli Pathogen-Host InteractionsR01AI126887 · NIAID · WASHINGTON UNIVERSITY · PI FLECKENSTEIN, JAMES MICHAEL · 2016 to 2020
$1.6M
NCATS NIH HHS UL1 TR002345NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI126887
6 · The paper itself

Abstract

Enterotoxigenic

Indexed as

Bacterial host responseBacterial infectionGastroenteritisLive attenuated vaccines

Identifiers

PMID31482013
PMCPMC6713706
OpenAlexW2970736061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.