Evidence map›Paper›PMID 31481982›Full record

ArticleDisease markers2019

Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer.

Xiao Jiang, Xiao-Yan Bai, Bowen Li, Yanan Li, Kangkai Xia, Miao Wang, Shujing Li, Huijian Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiao JiangKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Xiao-Yan BaiKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Bowen LiKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Yanan LiKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Kangkai XiaKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Miao WangKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Shujing LiKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.
Huijian WuKey Laboratory of Protein Modification and Disease of Liaoning Province, School of Life Science and Biotechnology, Dalian University of Technology, No. 2 Ling Gong Road, Dalian 116024, China.ORCID https://orcid.org/0000-0001-5257-0089
Dalian University of Technology · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveInter-alpha-trypsin inhibitor heavy chain H3 (ITIH

methodsIn total, 101 CRC patients and 156 healthy controls were enrolled. The concentrations of ITIH

resultsThe plasma concentration of ITIH

conclusionsCirculating ITIH

Indexed as

AgedAlpha-GlobulinsBiomarkers, TumorColorectal NeoplasmsFemaleHumansMaleMiddle AgedProteinase Inhibitory Proteins, SecretorySensitivity and SpecificityTissue Inhibitor of Metalloproteinase-1Alpha-GlobulinsBiomarkers, Tumorinter-alpha-inhibitorITIH4 protein, humanProteinase Inhibitory Proteins, SecretoryTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1

Identifiers

PMID31481982
PMCPMC6701429
OpenAlexW2964906956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.