ArticleFrontiers in immunology2019
Human Intestinal Enteroids Model MHC-II in the Gut Epithelium.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Intestinal Stem Cells From Patients With Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation.Cellular and molecular gastroenterology and hepatology · 2026Article
- Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells.BMC molecular and cell biology · 2025Article
- Revolutionizing immune research with organoid-based co-culture and chip systems.Clinical and experimental immunology · 2024Review
- Organoids as a tool to study homeostatic and pathological immune-epithelial interactions in the gut.Clinical and experimental immunology · 2024Review
- Inverted apicobasal polarity in health and disease.Journal of cell science · 2024Review
- Human intestinal epithelial cells can internalize luminal fungiFrontiers in immunology · 2023Article
- Bioengineered Co-culture of organoids to recapitulate host-microbe interactions.Materials today. Bio · 2022Review
- Differential Response to the Course of Cryptosporidium parvum Infection and Its Impact on Epithelial Integrity in Differentiated versus Undifferentiated Human Intestinal Enteroids.Infection and immunity · 2022Article
- Article
- Extended longevity geometrically-inverted proximal tubule organoids.Biomaterials · 2022Article
- Reciprocal Interactions Between Regulatory T Cells and Intestinal Epithelial Cells.Frontiers in immunology · 2022Review
- Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium.Frontiers in immunology · 2022Article
- Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases.Nature protocols · 2021Review
- Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ.Mucosal immunology · 2021Article
- Why do intestinal epithelial cells express MHC class II?Immunology · 2021Review
- Organoids: a promising new in vitro platform in livestock and veterinary research.Veterinary research · 2021Review
- Cancer Cell Invasion of Mammary Organoids with Basal-In Phenotype.Advanced healthcare materials · 2021Article
- Development of a human primary gut-on-a-chip to model inflammatory processes.Scientific reports · 2020Article
- Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells.Gastroenterology · 2020Article
- Regulation of NK-Cell Function by HLA Class II.Frontiers in cellular and infection microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functional in IECs. Our approach enables human enteroids to be used for novel
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.