ArticleFrontiers in cellular neuroscience2019
A Kinetic Map of the Homomeric Voltage-Gated Potassium Channel (Kv) Family.
Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed.
- Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species.Experimental physiology · 2026Article
- eFEL: electrophysiology feature extraction library.Bioinformatics (Oxford, England) · 2026Article
- One model to rule them all: Unification of voltage-gated potassium channel models via deep non-linear mixed effects modelling.PLoS computational biology · 2026Article
- Leveraging Electrochemical Diversity in Engineering Liquid-State Ionic Devices for Neuromorphic Computing.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- Cardiac resident macrophages: the emerging role in arrhythmogenesis.Frontiers in immunology · 2026Review
- KvThe Journal of physiology · 2025Article
- Pharmacological Actions of Potassium Channel Openers on Voltage-Gated Potassium Channels.Pharmaceuticals (Basel, Switzerland) · 2025Article
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- Heterochannels Kv(1.1-1.2)Cells · 2025Article
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- Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances.eLife · 2025Article
- Energy landscape of a Kv channel revealed by temperature steps while perturbing its electromechanical coupling.Nature communications · 2025Article
- An electrophysiologist's guide to dorsal horn excitability and pain.Frontiers in cellular neuroscience · 2025Review
- Inhibition of NMDA receptors and other ion channel types by membrane-associated drugs.Frontiers in pharmacology · 2025Review
- New High-Affinity Peptide Ligands for Kv1.2 Channel: Selective Blockers and Fluorescent Probes.Cells · 2024Article
- The potassium channel subunit KeLife · 2024Article
- Voltage Gated Ion Channels and Sleep.The Journal of membrane biology · 2024Review
- Electrical excitability of cancer cells-CELEX model updated.Cancer metastasis reviews · 2024Review
- A low-cost perfusion heating system for slice electrophysiology.Scientific reports · 2024Article
11 more citing papers are in PubMed but not listed here.
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully sequenced decades ago, a comprehensive kinetic characterization of all Kv channels is still missing, especially near physiological temperature. Here, we present a standardized kinetic map of the 40 homomeric Kv channels systematically characterized at 15, 25, and 35°C. Importantly, the Kv kinetics at 35°C differ significantly from commonly reported kinetics, usually performed at room temperature. We observed voltage-dependent Q
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