Evidence map›Paper›PMID 31481793›Full record

ReviewNature cell biology2019

The cell cycle in stem cell proliferation, pluripotency and differentiation.

Lijun Liu, Wojciech Michowski, Aleksandra Kolodziejczyk, Piotr Sicinski

Abstract readReview
In one paragraph

Review in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 236 papers.

0numbers the graph read from it
0cells of the map it votes in
236citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

236 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. CRL4EMBO reports · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. [Current status of intrauterine adhesion treatment and research progress in stem cell therapy].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. A new mRNA antigen vaccine induces potent B and T cell responses andbioRxiv : the preprint server for biology · 2026
    Article
  18. Article
  19. Review
  20. Article

176 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lijun LiuCollege of Life and Health Sciences, Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.ORCID http://orcid.org/0000-0002-0027-4525
Wojciech MichowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8901-7260
Aleksandra KolodziejczykDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1929-5254
Piotr SicinskiDepartment of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Peter_Sicinski@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-8859-5234

Funding

Cyclin A Function in Stem Cells and in NeoplasiaR01CA132740 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2008 to 2017
$4.4M
Novel functions of D-type and E-type cyclins in normal and in cancer cellsR01CA202634 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2016 to 2020
$2.1M
NCI NIH HHS R01 CA132740NCI NIH HHS R01 CA202634
6 · The paper itself

Abstract

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryonic neural stem/progenitor cells.

Indexed as

AnimalsCell CycleCell DifferentiationCell ProliferationEmbryonic Stem CellsHumansInduced Pluripotent Stem CellsPluripotent Stem Cells

Identifiers

PMID31481793
PMCPMC7065707

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.