ArticleScientific reports2019
Model of Anisotropic Reverse Cardiac Growth in Mechanical Dyssynchrony.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Effects of Purkinje Fiber Conduction Block on Cardiac Pump Function: Computational Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- Rapid prediction of cardiac activation in the left ventricle with geometric deep learning: a step towards cardiac resynchronization therapy planning.NPJ digital medicine · 2026Article
- Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease.Annals of biomedical engineering · 2024Article
- A multiscale finite element model of left ventricular mechanics incorporating baroreflex regulation.Computers in biology and medicine · 2024Article
- A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants.Journal of biomechanical engineering · 2023Article
- Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.Scientific reports · 2023Article
- Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model.Computers in biology and medicine · 2022Article
- Multiscale simulations of left ventricular growth and remodeling.Biophysical reviews · 2021Review
- Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing.American journal of physiology. Heart and circulatory physiology · 2021Article
- Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.Frontiers in physiology · 2021Article
- Mechanical stimuli for left ventricular growth during pressure overload.Experimental mechanics · 2021Article
- Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021Review
- Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation.Frontiers in physiology · 2020Article
- Review of cardiac-coronary interaction and insights from mathematical modeling.WIREs mechanisms of diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Based on recent single-cell experiments showing that longitudinal myocyte stretch produces both parallel and serial addition of sarcomeres, we developed an anisotropic growth constitutive model with elastic myofiber stretch as the growth stimuli to simulate long-term changes in biventricular geometry associated with alterations in cardiac electromechanics. The constitutive model is developed based on the volumetric growth framework. In the model, local growth evolutions of the myocyte's longitudinal and transverse directions are driven by the deviations of maximum elastic myofiber stretch over a cardiac cycle from its corresponding local homeostatic set point, but with different sensitivities. Local homeostatic set point is determined from a simulation with normal activation pattern. The growth constitutive model is coupled to an electromechanics model and calibrated based on both global and local ventricular geometrical changes associated with chronic left ventricular free wall pacing found in previous animal experiments. We show that the coupled electromechanics-growth model can quantitatively reproduce the following: (1) Thinning and thickening of the ventricular wall respectively at early and late activated regions and (2) Global left ventricular dilation as measured in experiments. These findings reinforce the role of elastic myofiber stretch as a growth stimulant at both cellular level and tissue-level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.