ArticleNature communications2019
Closed-loop control of gamma oscillations in the amygdala demonstrates their role in spatial memory consolidation.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease.International journal of molecular sciences · 2023Pooled it
- Gamma entrainment as a functional target in deep brain stimulation.Neural regeneration research · 2026Article
- Pentylenetetrazole kindling impairs place recognition memory associated with suppressing proBDNF-mediated neural information flows at the hippocampal CA3-CA1 synapses.Frontiers in pharmacology · 2026Article
- Concurrent observation and physical practice facilitates early closed motor skill learning: evidence from EEG source functional connectivity and behavioral performance.Frontiers in psychology · 2026Article
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- RpiBeh offers a versatile open source solution for rodent behavior tracking and closed loop interventions.Scientific reports · 2025Article
- Exploring individual differences in amygdala-mediated memory modulation.Cognitive, affective & behavioral neuroscience · 2025Article
- Major individual and regional variations in unit entrainment by oscillations of different frequencies.Scientific reports · 2025Article
- High gamma EEG responses to emotional stimuli in virtual reality: insights from local activation and distributed characteristics.Frontiers in human neuroscience · 2025Article
- Innovating beyond electrophysiology through multimodal neural interfaces.Nature reviews electrical engineering · 2025Article
- Mystery of gamma wave stimulation in brain disorders.Molecular neurodegeneration · 2024Review
- Arousal effects on oscillatory dynamics in the non-human primate brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
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- Article
- Unraveling Sex Differences in Affect Processing: Unique Oscillatory Signaling Dynamics in the Infralimbic Cortex and Nucleus Accumbens Shell.Biological psychiatry global open science · 2024Article
- Open Hardware Implementation of Real-Time Phase and Amplitude Estimation for Neurophysiologic Signals.Bioengineering (Basel, Switzerland) · 2023Article
- Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal-prefrontal-amygdala circuit in contextual fear.Scientific reports · 2023Article
- Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses.Journal of neuroendocrinology · 2023Review
- Theoretical Considerations for Optimizing the Use of Optogenetics with Complex Behavior.Current protocols · 2023Article
- Approaches to characterizing oscillatory burst detection algorithms for electrophysiological recordings.Journal of neuroscience methods · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Gamma is a ubiquitous brain rhythm hypothesized to support cognitive, perceptual, and mnemonic functions by coordinating neuronal interactions. While much correlational evidence supports this hypothesis, direct experimental tests have been lacking. Since gamma occurs as brief bursts of varying frequencies and durations, most existing approaches to manipulate gamma are either too slow, delivered irrespective of the rhythm's presence, not spectrally specific, or unsuitable for bidirectional modulation. Here, we overcome these limitations with an approach that accurately detects and modulates endogenous gamma oscillations, using closed-loop signal processing and optogenetic stimulation. We first show that the rat basolateral amygdala (BLA) exhibits prominent gamma oscillations during the consolidation of contextual memories. We then boost or diminish gamma during consolidation, in turn enhancing or impairing subsequent memory strength. Overall, our study establishes the role of gamma oscillations in memory consolidation and introduces a versatile method for studying fast network rhythms in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.