Evidence map›Paper›PMID 31481693›Full record

ArticleNature communications2019

Irrelevance of linear controllability to nonlinear dynamical networks.

Junjie Jiang, Ying-Cheng Lai

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Quantifying State-Dependent Control Properties of Brain Dynamics from Perturbation Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Identifying cancer driver genes in individual tumours.Computational and structural biotechnology journal · 2023
    Review
  6. Article
  7. NETISCE: a network-based tool for cell fate reprogramming.NPJ systems biology and applications · 2022
    Article
  8. Article
  9. The missing role of gray matter in studying brain controllability.Network neuroscience (Cambridge, Mass.) · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Junjie JiangSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ, 85287, USA.
Ying-Cheng LaiSchool of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, AZ, 85287, USA. ying-cheng.lai@asu.edu.ORCID http://orcid.org/0000-0002-0723-733X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been tremendous development in linear controllability of complex networks. Real-world systems are fundamentally nonlinear. Is linear controllability relevant to nonlinear dynamical networks? We identify a common trait underlying both types of control: the nodal "importance". For nonlinear and linear control, the importance is determined, respectively, by physical/biological considerations and the probability for a node to be in the minimum driver set. We study empirical mutualistic networks and a gene regulatory network, for which the nonlinear nodal importance can be quantified by the ability of individual nodes to restore the system from the aftermath of a tipping-point transition. We find that the nodal importance ranking for nonlinear and linear control exhibits opposite trends: for the former large-degree nodes are more important but for the latter, the importance scale is tilted towards the small-degree nodes, suggesting strongly the irrelevance of linear controllability to these systems. The recent claim of successful application of linear controllability to Caenorhabditis elegans connectome is examined and discussed.

Indexed as

Gene Regulatory NetworksNonlinear DynamicsAlgorithmsAnimalsCaenorhabditis elegansComputer SimulationMagnoliopsidaModels, BiologicalPollinationSaccharomyces cerevisiaeSymbiosisTranscription, Genetic

Identifiers

PMID31481693
PMCPMC6722065

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.