ArticleNature communications2019
Meiotic sex in Chagas disease parasite Trypanosoma cruzi.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- Genomic diversity of Trypanosoma cruzi clinical isolates: a retrospective analysis.The Lancet. Microbe · 2026Article
- Epidemiological dynamics ofMicrobial genomics · 2025Article
- Variation in surface protein expression leads to heterogeneous Trypanosoma cruzi populations during host cell infection.Nature communications · 2025Article
- ClinicalbioRxiv : the preprint server for biology · 2025Article
- Molecular and Genetic Analysis of the Increased Number of Genes forPathogens (Basel, Switzerland) · 2025Article
- The Relevance of the Predominant Clonal Evolution (PCE) Model for the Molecular Epidemiology and Subspecific Taxonomy ofPathogens (Basel, Switzerland) · 2025Review
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- Admixture in the fungal pathogen Blastomyces.Genetics · 2024Article
- Genetic Diversity ofLife (Basel, Switzerland) · 2024Review
- Interaction ofMicroorganisms · 2024Review
- Fifteen Years after the Definition ofLife (Basel, Switzerland) · 2023Review
- Differential expression of meiosis and homologous recombination-related genes in the life cycle of Trypanosoma cruzi.Parasitology research · 2023Article
- Genome diversity ofFrontiers in cellular and infection microbiology · 2023Article
- Genomic surveillance: a potential shortcut for effective Chagas disease management.Memorias do Instituto Oswaldo Cruz · 2023Article
- An Updated View of theACS infectious diseases · 2022Review
- Genome plasticity driven by aneuploidy and loss of heterozygosity inMicrobial genomics · 2022Article
- Microevolution ofeLife · 2022Article
- Sex in protists: A new perspective on the reproduction mechanisms of trypanosomatids.Genetics and molecular biology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Genetic exchange enables parasites to rapidly transform disease phenotypes and exploit new host populations. Trypanosoma cruzi, the parasitic agent of Chagas disease and a public health concern throughout Latin America, has for decades been presumed to exchange genetic material rarely and without classic meiotic sex. We present compelling evidence from 45 genomes sequenced from southern Ecuador that T. cruzi in fact maintains truly sexual, panmictic groups that can occur alongside others that remain highly clonal after past hybridization events. These groups with divergent reproductive strategies appear genetically isolated despite possible co-occurrence in vectors and hosts. We propose biological explanations for the fine-scale disconnectivity we observe and discuss the epidemiological consequences of flexible reproductive modes. Our study reinvigorates the hunt for the site of genetic exchange in the T. cruzi life cycle, provides tools to define the genetic determinants of parasite virulence, and reforms longstanding theory on clonality in trypanosomatid parasites.
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